RGD Reference Report - Fructose induces tubulointerstitial injury in the kidney of mice. - Rat Genome Database

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Fructose induces tubulointerstitial injury in the kidney of mice.

Authors: Aoyama, M  Isshiki, K  Kume, S  Chin-Kanasaki, M  Araki, H  Araki, S  Koya, D  Haneda, M  Kashiwagi, A  Maegawa, H  Uzu, T 
Citation: Aoyama M, etal., Biochem Biophys Res Commun. 2012 Mar 9;419(2):244-9. doi: 10.1016/j.bbrc.2012.02.001. Epub 2012 Feb 8.
RGD ID: 7245951
Pubmed: PMID:22342673   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2012.02.001   (Journal Full-text)

Fructose induces several kinds of human metabolic disorders; however, information regarding fructose-induced kidney injury is still limited. This study examined fructose-induced kidney injury in mice and clarified the differential susceptibility of three mouse strains: C57Bl/6J, CBA/JN and DBA/2N. In this study all mice were fed with an equal calorie count for sixteen weeks to remove the influence of total energy intake from metabolic effects by fructose-feeding. Only DBA/2N mice, but not C57Bl/6J and CBA/JN mice, fed with fructose displayed tubulointerstitial fibrosis localized on the outer cortex of the kidney together with the increase of mRNA expression of Kim1 and Ngal in the absence of distinct glomerular lesions and albuminuria - decidedly different from diabetic nephropathy. In time-course study of DBA/2N mice fed with fructose diet, the inflammation and fibrosis in the outer cortex of the kidney were enhancing after eight weeks, in parallel with the accumulation of oxidative stress. This progression of renal damage in DBA/2N mice was accompanied with increasing mRNA expression of GLUT5. These results suggest that the responsiveness of GLUT5 expression to fructose at the kidney is one of pivotal roles for the progression of fructose-induced kidney injury.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
renal fibrosis  ISOHavcr1 (Mus musculus)7245951; 7245951mRNA:increased expression:kidney cortex:RGD 
renal fibrosis  IEP 7245951; 7245951mRNA:increased expression:kidney cortex:RGD 
renal fibrosis  ISOLcn2 (Mus musculus)7245951; 7245951mRNA:increased expression:kidney cortex:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Havcr1  (hepatitis A virus cellular receptor 1)
Lcn2  (lipocalin 2)

Genes (Mus musculus)
Havcr1  (hepatitis A virus cellular receptor 1)
Lcn2  (lipocalin 2)

Genes (Homo sapiens)
HAVCR1  (hepatitis A virus cellular receptor 1)
LCN2  (lipocalin 2)


Additional Information