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Characterization of two genes, Impa1 and Impa2 encoding mouse myo-inositol monophosphatases.

Authors: Shamir, A  Sjoholt, G  Ebstein, RP  Agam, G  Steen, VM 
Citation: Shamir A, etal., Gene 2001 Jun 27;271(2):285-91.
Pubmed: (View Article at PubMed) PMID:11418250

The enzyme myo-inositol monophosphatase (Impa) catalyzes the synthesis of free myo-inositol from various myo-inositol monophosphates in the phosphatidylinositol signaling system. Impa is a lithium-blockable enzyme that has been hypothesized to be the biological target for lithium-salts used as mood-stabilizing drugs in the treatment of manic-depressive (bipolar) illness. As an initial step to explore the functional consequences of reduced or absent Impa activity in an animal model we here report the isolation of two Impa-encoding mouse genes, Impa1 and Impa2. Impa1 spans approximately 17.5 kb and contains nine exons of 46--1354 bp encoding a protein of 277 amino acids. Impa2 spans at least 19.5 kb and contains eight exons of 46--444 bp size encoding a protein of 290 amino acids. The genomic structure including the positions of the exon-intron splice sites seems to be conserved among myo-inositol monophosphatase genes in mammalian species. One or more Impa-like genes do also exist in evolutionary more distant species like invertebrates, plants and bacteria. The proteins encoded by the non-vertebrate genes seem to be equally related to Impa1 and Impa2. We therefore suggest that the Impa1 and Impa2 genes duplicated from a common ancestral gene after the evolutionary divergence of vertebrates.


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RGD Object Information
RGD ID: 724426
Created: 2003-10-03
Species: All species
Last Modified: 2003-10-03
Status: ACTIVE


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