RGD Reference Report - Vascular and Neuronal Protection Induced by the Ocular Administration of Nerve Growth Factor in Diabetic-Induced Rat Encephalopathy. - Rat Genome Database

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Vascular and Neuronal Protection Induced by the Ocular Administration of Nerve Growth Factor in Diabetic-Induced Rat Encephalopathy.

Authors: Tirassa, P  Maccarone, M  Florenzano, F  Cartolano, S  De Nicolo, S 
Citation: Tirassa P, etal., CNS Neurosci Ther. 2013 Mar 26. doi: 10.1111/cns.12085.
RGD ID: 7242845
Pubmed: PMID:23528019   (View Abstract at PubMed)
PMCID: PMC6493629   (View Article at PubMed Central)
DOI: DOI:10.1111/cns.12085   (Journal Full-text)

BACKGROUND: Based on our previous findings on the efficacy of ocular applied nerve growth factor as eye drops (oNGF) to act in brain and counteract neuronal damage, we hypothesized that oNGF treatment might revert neuronal atrophy occurring in diabetic brain also by controlling neurotrophin system changes. The major NGF brain target areas, such as the septum and the hippocampus, were used as an experimental paradigma to test this hypothesis. METHODS: Bilateral oNGF treatment was performed twice a day for 2 weeks in full-blown streptozotocin-treated adult male rats. The forebrain distribution of cholinergic and endothelial cell markers and NGF receptors were studied by confocal microscopy. The septo-hippocampal content of NGF mature and precursor form and NGF receptors expression were also analyzed by Elisa and Western blot. RESULTS: oNGF treatment recovers the morphological alterations and the neuronal atrophy in septum and normalized the expression of mature and pro-NGF, as well as NGF receptors in the septum and hippocampus of diabetic rats. In addition, oNGF stimulated brain vascularization and up-regulated the TRKA receptor in vessel endothelium. CONCLUSIONS: Our findings confirm that reduced availability of mature NGF and NGF signaling impairment favors vascular and neuronal alterations in diabetic septo-hippocampal areas and corroborate the ability of oNGF to act as a neuroprotective agent in brain.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NGFHumandiabetic encephalopathy treatmentISONgf (Mus musculus)associated with Diabetes Mellitus and ExperimentalRGD 
NGFRHumandiabetic encephalopathy treatmentISONgfr (Rattus norvegicus)associated with Diabetes Mellitus and ExperimentalRGD 
NgfMousediabetic encephalopathy treatmentIDA associated with Diabetes Mellitus and ExperimentalRGD 
NgfRatdiabetic encephalopathy treatmentISONgf (Mus musculus)associated with Diabetes Mellitus and ExperimentalRGD 
NgfrRatdiabetic encephalopathy treatmentIEP associated with Diabetes Mellitus and ExperimentalRGD 
NgfrMousediabetic encephalopathy treatmentISONgfr (Rattus norvegicus)associated with Diabetes Mellitus and ExperimentalRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ngf  (nerve growth factor)
Ngfr  (nerve growth factor receptor)

Genes (Mus musculus)
Ngf  (nerve growth factor)
Ngfr  (nerve growth factor receptor (TNFR superfamily, member 16))

Genes (Homo sapiens)
NGF  (nerve growth factor)
NGFR  (nerve growth factor receptor)


Additional Information