RGD Reference Report - Fcgamma receptor IIB and IIIB polymorphisms and susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis. - Rat Genome Database

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Fcgamma receptor IIB and IIIB polymorphisms and susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis.

Authors: Lee, YH  Ji, JD  Song, GG 
Citation: Lee YH, etal., Lupus. 2009 Jul;18(8):727-34. doi: 10.1177/0961203309104020.
RGD ID: 7240540
Pubmed: PMID:19502269   (View Abstract at PubMed)
DOI: DOI:10.1177/0961203309104020   (Journal Full-text)

The aim of this study was to explore whether polymorphisms of the Fcgamma receptors (FcgammaRs) IIB T/I232 and FcgammaRIIIB NA1/NA2, confer susceptibility to systemic lupus erythematosus (SLE) and lupus nephritis (LN). The authors conducted a meta-analysis on associations between the FcgammaRIIB T/I232 and FcgammaRIIIB NA1/NA2 polymorphisms and SLE and LN susceptibility as determined using 1) allele contrast, 2) recessive, 3) dominant models and 4) contrast of homozygotes. A total of 16 separate comparisons were considered, consisting of 2887 SLE patients and 3105 controls. Meta-analysis of the FcgammaRIIB T/I232 polymorphism showed a significant association between the FcgammaRIIB T allele and the risk of developing SLE compared with the FcgammaRIIB I allele (OR = 1.207, 95% CI = 1.061-1.373, P = 0.004). In subjects of Asian descent, a significant association was observed between the FcgammaRIIB T allele and SLE (OR = 1.332, 95% CI 1.138-1.558, P < 0.001). However, in Europeans no such association was found. In contrast, no association was found between SLE or LN and the FcgammaRIIIB NA1/NA2 polymorphism in all subjects, or in European and Asian populations. This meta-analysis shows that the FcgammaRIIB T/I232 polymorphism confers susceptibility to SLE, especially in Asian-derived populations.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
systemic lupus erythematosus  IAGP 7240540 RGD 
systemic lupus erythematosus  ISOFCGR2B (Homo sapiens)7240540; 7240540 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fcgr2b  (Fc gamma receptor 2B)

Genes (Mus musculus)
Fcgr2b  (Fc receptor, IgG, low affinity IIb)

Genes (Homo sapiens)
FCGR2B  (Fc gamma receptor IIb)


Additional Information