RGD Reference Report - [Effects of yiqi huoxue compound combined with exercise therapy on MMP-1 and collagen type III expressions of cardiac muscle in chronic heart failure rats].

General

[Effects of yiqi huoxue compound combined with exercise therapy on MMP-1 and collagen type III expressions of cardiac muscle in chronic heart failure rats].
Authors:	Li, H Zhang, Y Ma, J
Citation:	Li H, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Jul;31(7):955-60.
RGD ID:	7207282
Pubmed:	PMID:21866669 (View Abstract at PubMed)
OBJECTIVE: To study the effects and mechanisms of Yiqi Huoxue Compound combined with exercise therapy on the ventricular remodeling of chronic heart failure (CHF) rats after myocardial infarction. METHODS: Eight rats were selected from sixty healthy SD rats as the blank control group, and the rest was used to prepare CHF rat model by coronary artery ligation in combination with exhausted swimming and food reducing. The successfully modeled rats were randomly divided into five groups, i. e., the model group (n = 8), the Chinese medicine group (n = 8), the Western medicine group (n = 8), the Chinese medicine + exercise group (n = 10), and the exercise group (n = 10). Routine gastrogavage of equal volume distilled water was given to rats in the blank control group and the model group respectively, 3 mL each time. Yiqi Huoxue Compound was given by gastrogavage to rats in the Chinese medicine group and the Chinese medicine + exercise group at the daily dose of 9.2 g crude drug/kg. Lisinopril was given by gastrogavage to rats in the Western medicine group at the daily dose of 1.5 mg crude drug/kg. The medication was administered twice daily for six successive weeks. The Chinese medicine + exercise group and the exercise group adopted exercise therapy, once daily. The myocardial tissue of rats' non-infarcted left ventricle was taken out. mRNA and protein contents of matrix metalloproteinase-1 (MMP-1) and collagen type III were detected by Real-time fluorescent quantitation PCR. RESULTS: Compared with the blank control group, the mRNA expression and the average gray value of MMP-1 increased, while those of collagen type III decreased in the model group, showing statistical difference (P<0.05, P<0.01). Compared with the model group, the mRNA expression and the average gray value of MMP-1 decreased in the Chi- nese medicine group, the Western medicine group, and the Chinese medicine + exercise group, showing statistical significance (P<0.01). It was lowest in the Chinese medicine + exercise group. The mRNA expression and the average gray value of collagen type III increased in the Western medicine group and the Chinese medicine + exercise group, showing statistical difference (P<0.01). CONCLUSIONS: Yiqi Huoxue Compound combined wih exercise therapy could attenuate the ventricular remodeling degree. Its mechanism might be to inhibit the MMP-1 expression, improve the expression of collagen type III, thus alleviating and even reversing myocardial fibrosis.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
congestive heart failure		ISO	Mmp1 (Rattus norvegicus)	7207282; 7207282		RGD
congestive heart failure		IDA		7207282		RGD

Objects Annotated

Genes (Rattus norvegicus)

Mmp1 (matrix metallopeptidase 1)

Genes (Mus musculus)

Mmp1a (matrix metallopeptidase 1a (interstitial collagenase))

Genes (Homo sapiens)

MMP1 (matrix metallopeptidase 1)

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[Effects of yiqi huoxue compound combined with exercise therapy on MMP-1 and collagen type III expressions of cardiac muscle in chronic heart failure rats].