RGD Reference Report - Hyperresistinemia - a novel feature in systemic infection during human pregnancy. - Rat Genome Database

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Hyperresistinemia - a novel feature in systemic infection during human pregnancy.

Authors: Mazaki-Tovi, S  Vaisbuch, E  Romero, R  Kusanovic, JP  Chaiworapongsa, T  Kim, SK  Ogge, G  Yoon, BH  Dong, Z  Gonzalez, JM  Gervasi, MT  Hassan, SS 
Citation: Mazaki-Tovi S, etal., Am J Reprod Immunol. 2010 May;63(5):358-69. doi: 10.1111/j.1600-0897.2010.00809.x. Epub 2010 Feb 18.
RGD ID: 7207160
Pubmed: PMID:20178460   (View Abstract at PubMed)
PMCID: PMC3426318   (View Article at PubMed Central)
DOI: DOI:10.1111/j.1600-0897.2010.00809.x   (Journal Full-text)

PROBLEM: Resistin, originally described as an adipokine, has emerged as a potent pro-inflammatory protein associated with both acute and chronic inflammation. Moreover, resistin has been proposed as a powerful marker of sepsis severity, as well as a predictor of survival of critically ill non-pregnant patients. The aim of this study was to determine whether pyelonephritis during pregnancy is associated with changes in maternal plasma resistin concentrations. METHODS OF STUDY: This cross-sectional study included the following groups: (i) normal pregnant women (n = 85) and (ii) pregnant women with pyelonephritis (n = 40). Maternal plasma resistin concentrations were determined by ELISA. Non-parametric statistics was used for analyses. RESULTS: (i) The median maternal plasma resistin concentration was higher in patients with pyelonephritis than in those with a normal pregnancy (P < 0.001); (ii) among patients with pyelonephritis, the median maternal resistin concentration did not differ significantly between those with and without a positive blood culture (P = 0.3); (iii) among patients with pyelonephritis who were diagnosed with systemic inflammatory response syndrome (SIRS), those who fulfilled > or =3 criteria for SIRS had a significantly higher median maternal plasma resistin concentration than those who met only two criteria; and (iv) maternal WBC count positively correlated with circulating resistin concentration (r = 0.47, P = 0.02). CONCLUSION: Hyperresistinemia is a feature of acute pyelonephritis during pregnancy. The results of this study support the role of resistin as an acute-phase protein in the presence of bacterial infection during pregnancy.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
RETNHumanpyelonephritis  IEP protein:increased expression:plasmaRGD 
RetnRatpyelonephritis  ISORETN (Homo sapiens)protein:increased expression:plasmaRGD 
RetnMousepyelonephritis  ISORETN (Homo sapiens)protein:increased expression:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Retn  (resistin)

Genes (Mus musculus)
Retn  (resistin)

Genes (Homo sapiens)
RETN  (resistin)


Additional Information