RGD Reference Report - A HindIII polymorphism of fibronectin gene is associated with nephrolithiasis. - Rat Genome Database

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A HindIII polymorphism of fibronectin gene is associated with nephrolithiasis.

Authors: Onaran, M  Yilmaz, A  Sen, I  Ergun, MA  Camtosun, A  Kupeli, B  Menevse, S  Bozkirli, I 
Citation: Onaran M, etal., Urology. 2009 Nov;74(5):1004-7. doi: 10.1016/j.urology.2009.05.010. Epub 2009 Jul 17.
RGD ID: 7206842
Pubmed: (View Article at PubMed) PMID:19616291
DOI: Full-text: DOI:10.1016/j.urology.2009.05.010

OBJECTIVES: To evaluate the association between fibronectin gene (FN1) polymorphisms and calcium oxalate nephrolithiasis as a genetic risk factor. METHODS: Genomic DNA of 143 patients with calcium oxalate nephrolithiasis and 154 healthy controls were screened for polymorphisms (HaeIII b, MspI, and HindIII) of the FN1 gene, using polymerase chain reaction-restriction fragments length polymorphism method. Allele and genotype frequencies were compared between the groups. RESULTS: Although the observed differences between distribution of genotypes of AA, AB, and BB (for HaeIII b), as well as CC, CD, and DD (MspI) were not significant, FF genotype for HindIII showed significant difference when compared with both EF and EE + EF genotype (P = .00202 and P = .00203, respectively). CONCLUSIONS: The results of our study revealed that HindIII polymorphism of the FN1 gene is highly associated with calcium oxalate stone disease. This association makes FN a good candidate for further studies about the etiology of stone disease, and in the future it could be a candidate marker for evaluating the genetic risks in patients with nephrolithiasis.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Fn1  (fibronectin 1)

Genes (Mus musculus)
Fn1  (fibronectin 1)

Genes (Homo sapiens)
FN1  (fibronectin 1)


Additional Information