RGD Reference Report - Distribution of tenascin-C, fibronectin and collagen types III and IV during regeneration of rat submandibular gland. - Rat Genome Database

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Distribution of tenascin-C, fibronectin and collagen types III and IV during regeneration of rat submandibular gland.

Authors: Ueda, K  Shimizu, O  Oka, S  Saito, M  Hide, M  Matsumoto, M 
Citation: Ueda K, etal., Int J Oral Maxillofac Surg. 2009 Jan;38(1):79-84. doi: 10.1016/j.ijom.2008.11.004. Epub 2008 Dec 18.
RGD ID: 7205460
Pubmed: (View Article at PubMed) PMID:19097859
DOI: Full-text: DOI:10.1016/j.ijom.2008.11.004

The aim of this study was to determine the localization of tenascin-C, fibronectin and collagen types III and IV during regeneration of the rat submandibular gland. After 7 days' obstruction, the regenerating glands were collected at days 0, 1, 3, 5, 7, 11 and 14 after duct release to study regeneration. Immunohistochemical staining revealed that tenascin-C was strongly expressed in the epithelial cells of duct-acinar structures at days 0-3, and down-regulated in its expression from day 5 to 11, though weak expression was detected in the intercalated duct and acinar cells of the normal gland. Strong labeling of fibronectin was detected around duct-acinar structures during days 0-3 of regeneration. Type IV collagen was expressed strongly in the thickened basement membrane of acinar cells and duct-acinar structures during days 0-3, but weakly around large ducts, though type III collagen was expressed at consistent levels. These findings suggest that tenascin-C and fibronectin affect only the duct-acinar structures, and type IV but not type III collagen is involved in the regeneration of acinar cells.



Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Fn1  (fibronectin 1)

Genes (Mus musculus)
Fn1  (fibronectin 1)

Genes (Homo sapiens)
FN1  (fibronectin 1)


Additional Information