RGD Reference Report - Effects of Adrenomedullin on Tumour Necrosis Factor Alpha, Interleukins, Endothelin-1, Leptin, and Adiponectin in the Epididymal Fat and Soleus Muscle of the Rat. - Rat Genome Database

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Effects of Adrenomedullin on Tumour Necrosis Factor Alpha, Interleukins, Endothelin-1, Leptin, and Adiponectin in the Epididymal Fat and Soleus Muscle of the Rat.

Authors: Liao, SB  Wong, PF  Cheung, BM  Tang, F  Tang, F 
Citation: Liao SB, etal., Horm Metab Res. 2012 Sep 6.
RGD ID: 7204716
Pubmed: PMID:22956308   (View Abstract at PubMed)
DOI: DOI:10.1055/s-0032-1321879   (Journal Full-text)

Adrenomedullin (ADM) is a peptide hormone, which participates in the development of metabolic syndrome. In this study, we have investigated the interaction of ADM and cytokines, endothelin-1 (EDN-1) and adipokines in the epididymal fat and the soleus muscle. Epididymal fat and soleus muscles from adult male Sprague-Dawley rat were incubated with ADM at concentration of 100 nM for the study of the gene expression and secretion of tumour necrosis factor (TNF-alpha), EDN-1, leptin, adiponectin, interleukin 1beta (IL-1beta), and IL-6. The effects of TNF-alpha and EDN-1 on ADM gene expression and secretion were also investigated. The results showed that ADM decreased the gene expression and protein secretion of TNF-alpha in both the epididymal fat and the soleus muscle and decreased IL-1beta gene expression and secretion in the soleus muscle. It also decreased endothelin gene expression and adiponectin gene expression and release and increased IL-6 and leptin gene expression and secretion in the epididymal fat. These effects were effectively blocked by the calcitonin gene-related peptide (CGRP) receptor antagonist, hCGRP8-37, but not by the ADM receptor antagonist, hADM22-52. The reduction of inflammatory cytokines and EDN-1 may help to decrease insulin resistance and increase glucose uptake. As TNF-alpha also increases ADM levels in the epididymal fat and the soleus muscle and EDN-1 also increases ADM levels in the epididymal fat, they may form a feedback loop with ADM in these tissues. The increase in leptin and the decrease in adiponectin by ADM in the epididymal fat may have opposite effects on metabolism.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to peptide hormone  IEP 7204716adrenomedullinRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1b  (interleukin 1 beta)


Additional Information