RGD Reference Report - STIM proteins: dynamic calcium signal transducers. - Rat Genome Database

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STIM proteins: dynamic calcium signal transducers.

Authors: Soboloff, J  Rothberg, BS  Madesh, M  Gill, DL 
Citation: Soboloff J, etal., Nat Rev Mol Cell Biol. 2012 Sep;13(9):549-65. doi: 10.1038/nrm3414.
RGD ID: 7204692
Pubmed: PMID:22914293   (View Abstract at PubMed)
PMCID: PMC3458427   (View Article at PubMed Central)
DOI: DOI:10.1038/nrm3414   (Journal Full-text)

Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of cellular calcium (Ca(2+)) signals. Spanning the endoplasmic reticulum (ER) membrane, they sense tiny changes in the levels of Ca(2+) stored within the ER lumen. As ER Ca(2+) is released to generate primary Ca(2+) signals, STIM proteins undergo an intricate activation reaction and rapidly translocate into junctions formed between the ER and the plasma membrane. There, STIM proteins tether and activate the highly Ca(2+)-selective Orai channels to mediate finely controlled Ca(2+) signals and to homeostatically balance cellular Ca(2+). Details are emerging on the remarkable organization within these STIM-induced junctional microdomains and the identification of new regulators and alternative target proteins for STIM.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ORAI1Humancalcium transport pathway   TAS  RGD 
ORAI2Humancalcium transport pathway   TAS  RGD 
ORAI3Humancalcium transport pathway   TAS  RGD 
Orai1Ratcalcium transport pathway   ISOORAI1 (Homo sapiens) RGD 
Orai1Mousecalcium transport pathway   ISOORAI1 (Homo sapiens) RGD 
Orai2Ratcalcium transport pathway   ISOORAI2 (Homo sapiens) RGD 
Orai2Mousecalcium transport pathway   ISOORAI2 (Homo sapiens) RGD 
Orai3Ratcalcium transport pathway   ISOORAI3 (Homo sapiens) RGD 
Orai3Mousecalcium transport pathway   ISOORAI3 (Homo sapiens) RGD 
STIM1Humancalcium transport pathway   TAS  RGD 
STIM2Humancalcium transport pathway   TAS  RGD 
Stim1Ratcalcium transport pathway   ISOSTIM1 (Homo sapiens) RGD 
Stim1Mousecalcium transport pathway   ISOSTIM1 (Homo sapiens) RGD 
Stim2Ratcalcium transport pathway   ISOSTIM2 (Homo sapiens) RGD 
Stim2Mousecalcium transport pathway   ISOSTIM2 (Homo sapiens) RGD 
ORAI1Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
ORAI2Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
ORAI3Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
Orai1Mousecalcium/calcium-mediated signaling pathway   ISOORAI1 (Homo sapiens) RGD 
Orai1Ratcalcium/calcium-mediated signaling pathway   ISOORAI1 (Homo sapiens) RGD 
Orai2Mousecalcium/calcium-mediated signaling pathway   ISOORAI2 (Homo sapiens) RGD 
Orai2Ratcalcium/calcium-mediated signaling pathway   ISOORAI2 (Homo sapiens) RGD 
Orai3Mousecalcium/calcium-mediated signaling pathway   ISOORAI3 (Homo sapiens) RGD 
Orai3Ratcalcium/calcium-mediated signaling pathway   ISOORAI3 (Homo sapiens) RGD 
STIM1Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
STIM2Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
Stim1Mousecalcium/calcium-mediated signaling pathway   ISOSTIM1 (Homo sapiens) RGD 
Stim1Ratcalcium/calcium-mediated signaling pathway   ISOSTIM1 (Homo sapiens) RGD 
Stim2Ratcalcium/calcium-mediated signaling pathway   ISOSTIM2 (Homo sapiens) RGD 
Stim2Mousecalcium/calcium-mediated signaling pathway   ISOSTIM2 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Orai1  (ORAI calcium release-activated calcium modulator 1)
Orai2  (ORAI calcium release-activated calcium modulator 2)
Orai3  (ORAI calcium release-activated calcium modulator 3)
Stim1  (stromal interaction molecule 1)
Stim2  (stromal interaction molecule 2)

Genes (Mus musculus)
Orai1  (ORAI calcium release-activated calcium modulator 1)
Orai2  (ORAI calcium release-activated calcium modulator 2)
Orai3  (ORAI calcium release-activated calcium modulator 3)
Stim1  (stromal interaction molecule 1)
Stim2  (stromal interaction molecule 2)

Genes (Homo sapiens)
ORAI1  (ORAI calcium release-activated calcium modulator 1)
ORAI2  (ORAI calcium release-activated calcium modulator 2)
ORAI3  (ORAI calcium release-activated calcium modulator 3)
STIM1  (stromal interaction molecule 1)
STIM2  (stromal interaction molecule 2)


Additional Information