RGD Reference Report - Induction of CD14 in tubular epithelial cells during kidney disease. - Rat Genome Database

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Induction of CD14 in tubular epithelial cells during kidney disease.

Authors: Morrissey, J  Guo, G  McCracken, R  Tolley, T  Klahr, S 
Citation: Morrissey J, etal., J Am Soc Nephrol. 2000 Sep;11(9):1681-90.
RGD ID: 7204444
Pubmed: PMID:10966493   (View Abstract at PubMed)

Analysis of gene expression in a mouse model of unilateral ureteral obstruction (UUO) revealed significant induction of CD14 mRNA in kidneys with obstructed ureters. Immunocytochemical analysis indicated that CD14 was upregulated in tubular epithelial cells and this upregulation was not attributable to infiltration of the kidneys by mononuclear cells. This induction of CD14 mRNA was found to occur in BALB/C, C57BL/6, C3H/HeN, and C3H/HeJ mice during UUO. Ischemia/reperfusion of kidneys also induced CD14 mRNA. Mice lacking either of the tumor necrosis factor-alpha receptor (TNFR) genes were also studied; the induction of CD14 was blunted in TNFR 1-knockout mice but not in TNFR2-knockout mice. Apoptosis of tubular cells in lipopolysaccharide-resistant CH3/HeJ mice was significantly (P: < 0. 05) less than that in lipopolysaccharide-responsive CH3/HeN mice during UUO. These results suggest that CD14 is acutely induced in tubular epithelial cells in two mouse models of renal injury. This induction is regulated by tumor necrosis factor-alpha, through TNFR1. CD14 may participate in the apoptosis of tubular epithelial cells on a more chronic basis by activating a pathway that is absent or deficient in C3H/HeJ mice.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Kidney Reperfusion Injury  ISOCd14 (Mus musculus)7204444; 7204444mRNA and protein:increased expression:kidneyRGD 
Kidney Reperfusion Injury  IEP 7204444mRNA and protein:increased expression:kidneyRGD 
ureteral obstruction  ISOCd14 (Mus musculus)7204444; 7204444mRNA and protein:increased expression:kidneyRGD 
ureteral obstruction  IEP 7204444mRNA and protein:increased expression:kidneyRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd14  (CD14 molecule)

Genes (Mus musculus)
Cd14  (CD14 antigen)

Genes (Homo sapiens)
CD14  (CD14 molecule)


Additional Information