RGD Reference Report - Huntingtin-interacting protein-1-related protein of rat (rHIP1R) is localized in the postsynaptic regions. - Rat Genome Database

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Huntingtin-interacting protein-1-related protein of rat (rHIP1R) is localized in the postsynaptic regions.

Authors: Okano, A  Usuda, N  Furihata, K  Nakayama, K  Bao Tian, Q  Okamoto, T  Suzuki, T 
Citation: Okano A, etal., Brain Res 2003 Mar 28;967(1-2):210-25.
RGD ID: 708599
Pubmed: PMID:12650982   (View Abstract at PubMed)

We cloned a rHIP1R (GenBank Accession No., AB005052) encoding a Sla2/huntingtin-interacting protein (HIP1) family protein from a rat brain cDNA library. Localization of rHIP1R was investigated in the rat brain using an antibody specific to the HIP1R antibody. The rHIP1R protein was enriched in the synaptic plasma membrane fraction along with huntingtin, a synaptic protein and a causal protein for Huntington's disease. The electron microscopic examination revealed that HIP1R was localized at postsynaptic spines. Localization of HIP1R in the small vesicular structures in the spine, possible sites of vesicular transport of synaptic proteins, together with the structure-based analysis, suggested a role of HIP1R for vesicle trafficking through interaction with F-actin and working together with huntingtin and HIP1 at the synaptic sites.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Hip1rRatglutamatergic synapse is_active_inIEP PMID:12650982SynGO 
Hip1rRatglutamatergic synapse is_active_inIDA PMID:12650982SynGO 
Hip1rRatpostsynapse is_active_inIDA PMID:12650982SynGO 
Hip1rRatpostsynapse is_active_inIEP PMID:12650982SynGO 
HttRatsynaptic membrane located_inIDA PMID:12650982ParkinsonsUK-UCL 

Objects Annotated

Genes (Rattus norvegicus)
Hip1r  (huntingtin interacting protein 1 related)
Htt  (huntingtin)


Additional Information