RGD Reference Report - Alleles of the spontaneously hypertensive rat decrease blood pressure at loci on chromosomes 4 and 13. - Rat Genome Database

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Alleles of the spontaneously hypertensive rat decrease blood pressure at loci on chromosomes 4 and 13.

Authors: Kovacs, P  Voigt, B  Kloting, I 
Citation: Kovacs P, etal., Biochem Biophys Res Commun 1997 Sep 18;238(2):586-9.
RGD ID: 70857
Pubmed: (View Article at PubMed) PMID:9299556
DOI: Full-text: DOI:10.1006/bbrc.1997.7342

In this study the spontaneously hypertensive rat (SHR/Mol) and the spontaneously diabetic BB/OK rat were crossed, and the F1 hybrids were backcrossed onto the BB/OK rat in order to search for cosegregation between blood pressure and loci on chromosomes 4 and 13. Cosegregation of microsatellites on chromosomes 4 (Spr, Npy, D4mit6, Il-6) and 13 (Atp1a2, D13Mit1, D13Uwm1) with blood pressure was evaluated using one-way analysis of variance. On chromosome 4 linkage of the Npy and D4Mit6 markers to systolic blood pressure was observed. A blood pressure QTL was also found on chromosome 13 within the renin locus. Surprisingly, alleles of the SHR strain at loci showing linkage to blood pressure on chromosome 4 and 13 promote lower blood pressure than the same alleles from the BB/OK strain. The transfer of D4Mit6 and renin locus from the SHR rat onto the genetic background of BB/OK rat will probably not lead to a model of diabetic hypertension, but the thorough characterisation of such congenics could contribute to the explanation of genetics and pathophysiology of hypertension in the SHR rat.

Annotation

Disease Annotations    
hypertension  (IDA)

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Bp79  (Blood pressure QTL 79)
Bp80  (Blood pressure QTL 80)
Bp9  (Blood pressure QTL 9)


Additional Information