RGD Reference Report - Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs. - Rat Genome Database

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Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs.

Authors: Kirchhausen, T  Scarmato, P  Harrison, SC  Monroe, JJ  Chow, EP  Mattaliano, RJ  Ramachandran, KL  Smart, JE  Ahn, AH  Brosius, J 
Citation: Kirchhausen T, etal., Science 1987 Apr 17;236(4799):320-4.
RGD ID: 70686
Pubmed: PMID:3563513   (View Abstract at PubMed)

The clathrin light chains fall into two major classes, LCA and LCB. In an intact clathrin triskelion, one light chain, of either class, is bound to the proximal segment of a heavy chain leg. Analysis of rat brain and liver complementary DNA clones for LCA and LCB shows that the two light chain classes are closely related. There appear to be several members of each class having deletions of varying length aligned at the same position. A set of ten heptad elements, characteristic of alpha-helical coiled coils, is a striking feature of the central part of each derived amino acid sequence. These observations suggest a model in which the alpha-helical segment mediates binding to clathrin heavy chains and the amino- and carboxyl-terminal segments mediate interactions with other proteins. They also suggest an explanation for the observed tissue-dependent size variation for members of each class.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CltbRatneurotransmitter secretion involved_inNAS PMID:3563513UniProt 
CltbRatneurotransmitter transport involved_inNAS PMID:3563513UniProt 
CltbRatsynaptic vesicle coating involved_inNAS PMID:3563513UniProt 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CltaRatclathrin coat of coated pit  NAS  RGD 
CltbRatclathrin coat of coated pit part_ofNAS PMID:3563513UniProt 
CltbRatclathrin coat of coated pit  NAS  RGD 
CltaRatclathrin vesicle coat  NAS  RGD 
CltbRatclathrin vesicle coat part_ofNAS PMID:3563513UniProt 
CltbRatclathrin vesicle coat  NAS  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CltbRatneurotransmitter transmembrane transporter activity enablesNAS PMID:3563513UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Clta  (clathrin, light chain A)
Cltb  (clathrin, light chain B)


Additional Information