RGD Reference Report - Molecular cloning of a levocabastine-sensitive neurotensin binding site. - Rat Genome Database

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Molecular cloning of a levocabastine-sensitive neurotensin binding site.

Authors: Chalon, P  Vita, N  Kaghad, M  Guillemot, M  Bonnin, J  Delpech, B  Le Fur, G  Ferrara, P  Caput, D 
Citation: Chalon P, etal., FEBS Lett 1996 May 20;386(2-3):91-4.
RGD ID: 70631
Pubmed: PMID:8647296   (View Abstract at PubMed)

A search for sequences homologous to the neurotensin receptor cDNA in a rat hypothalamic library has identified a novel neurotensin receptor (NTR-2). The 1539 bp cDNA encodes a 416 amino acid protein and shows highest homology to the previously cloned neurotensin receptor (NTR-1) (64% homology and 43% identity). Binding and pharmacological studies demonstrate that NTR-2 expressed in COS cells recognizes neurotensin (NT) with high affinity as well as several other agonists and antagonists. However, a fundamental difference was found; unlike NTR-1, NTR-2 recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with NT for low-affinity binding sites in brain.

Objects referenced in this article
Gene NTSR2 neurotensin receptor 2 Homo sapiens
Gene Ntsr2 neurotensin receptor 2 Rattus norvegicus

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