RGD Reference Report - Congenic mapping of a blood pressure QTL on Chromosome 16 of Dahl rats. - Rat Genome Database

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Congenic mapping of a blood pressure QTL on Chromosome 16 of Dahl rats.

Authors: Moujahidine, M  Dutil, J  Hamet, P  Deng, AY 
Citation: Moujahidine M, etal., Mamm Genome 2002 Mar;13(3):153-6.
RGD ID: 70460
Pubmed: (View Article at PubMed) PMID:11919686
DOI: Full-text: DOI:10.1007/s00335-001-2138-3

A Chromosome (Chr) 16 segment of the Dahl salt-sensitive (S) rat was shown by linkage to contain a blood pressure (BP) quantitative trait locus (QTL). To verify and further narrow down the region harboring the QTL, we made two congenic strains by replacing two segments of the S rats with the homologous segments of the Lewis (LEW) rats. The construction of these congenic strains was facilitated by a genome-wide marker screening. The two congenic strains contained a segment in common, and BPs of both were significantly lower than that of the S strain. Consequently, a BP QTL could be localized to the overlapping region of about 49.4 centiRay (cR) including the telomere on a radiation hybrid map. Heart weights, left and right ventricular weights, kidney weights, and aortic weights over length were all significantly decreased in the congenic strains compared with the S strain. Thus, there appeared to exist an association between the effects of the QTL on BP and on cardiac, renal, and vascular hypertrophy.



Disease Annotations    
hypertension  (IDA)


Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Strains with Phenominer Data Strains with phenominer dataStrains with phenominer data
SS.LEW-(D16Uia2-D16Rat12)/Ayd SS.LEW-(D16Mit2-D16Rat12)/Ayd SS/Jr

Objects Annotated

QTLs
Bp75  (Blood pressure QTL 75)


Additional Information