RGD Reference Report - Upregulation of class II histone deacetylases mRNA during neural differentiation of cultured rat hippocampal progenitor cells. - Rat Genome Database

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Upregulation of class II histone deacetylases mRNA during neural differentiation of cultured rat hippocampal progenitor cells.

Authors: Ajamian, F  Suuronen, T  Salminen, A  Reeben, M 
Citation: Ajamian F, etal., Neurosci Lett 2003 Jul 31;346(1-2):57-60.
RGD ID: 704464
Pubmed: PMID:12850547   (View Abstract at PubMed)

We studied the expression of histone deacetylases (HDACs 1-10) mRNAs during early differentiation of cultured rat hippocampal progenitor cells using Northern blot analysis. Embryonic rat hippocampal progenitors were kept proliferating and undifferentiated (neurospheres) in the presence of mitogens and induced to stop proliferation and to differentiate into neurons and astrocytes by mitogen removal. We found two- to four-fold elevated levels of mRNAs for HDAC 5, 6, 7 and 9 in early differentiation times in comparison with proliferating neurospheres while mRNA levels for HDAC 1, 2 and 3 did not change significantly. Interestingly, the upregulated HDACs all belong to class II of histone deacetylases. mRNAs for HDAC 4, 8 and 10 were not detectable by Northern analysis. We suggest that the changes in HDAC mRNA expression levels might be connected with chromatin rearrangement during neural differentiation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
neuron differentiation  IEP 704464; 704464; 704464; 704464 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hdac5  (histone deacetylase 5)
Hdac6  (histone deacetylase 6)
Hdac7  (histone deacetylase 7)
Hdac9  (histone deacetylase 9)

Objects referenced in this article
Gene Hdac2 histone deacetylase 2 Rattus norvegicus

Additional Information