RGD Reference Report - Multiple blood pressure QTL on rat Chromosome 2 defined by congenic Dahl rats. - Rat Genome Database

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Multiple blood pressure QTL on rat Chromosome 2 defined by congenic Dahl rats.

Authors: Garrett, MR  Rapp, JP 
Citation: Garrett MR and Rapp JP, Mamm Genome 2002 Jan;13(1):41-4.
RGD ID: 70380
Pubmed: PMID:11773968   (View Abstract at PubMed)

Linkage analysis previously demonstrated a blood pressure quantitative trait locus (QTL) on rat Chromosome 2 (Chr 2) in crosses utilizing Dahl salt-sensitive (S) rats. The present work dissects this QTL by using congenic strains in which segments of Chr 2 from Wistar Kyoto rats (WKY) are placed on the S genetic background. Two distinct QTLs were found where one QTL was anticipated. These each accounted for a blood pressure of 15-20 mm Hg in rats fed 2% NaCl diet for 24 days. One QTL was in the <9-cM interval between D2Rat35 and D2Wox18 (Fgg), and the other was in the <7-cM interval between D2Wox18 (Fgg) and D2Mgh10. A third tentative QTL was suggested, but not clearly established, in the <3-cM interval between D2Mgh10 and D2Rat259.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp73Rathypertension  IDA  RGD 
Bp74Rathypertension  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp73Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp74Ratincreased systemic arterial blood pressure  QTM  RGD 
Objects Annotated

QTLs
Bp73  (Blood pressure QTL 73)
Bp74  (Blood pressure QTL 74)

Objects referenced in this article
QTL Bp10 Blood pressure QTL 10 Rattus norvegicus
QTL Bp19 Blood pressure QTL 19 Rattus norvegicus
Strain SS.WKY-(D2N35-Mme)/Mco null Rattus norvegicus

Additional Information