RGD Reference Report - Thyroid hormone is a critical determinant for the regulation of the cochlear motor protein prestin. - Rat Genome Database
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Thyroid hormone is a critical determinant for the regulation of the cochlear motor protein prestin.

Authors: Weber, T  Zimmermann, U  Winter, H  Mack, A  Kopschall, I  Rohbock, K  Zenner, HP  Knipper, M 
Citation: Weber T, etal., Proc Natl Acad Sci U S A 2002 Mar 5;99(5):2901-6.
RGD ID: 70328
Pubmed: (View Article at PubMed) PMID:11867734
DOI: Full-text: DOI:10.1073/pnas.052609899

The most impressive property of outer hair cells (OHCs) is their ability to change their length at high acoustic frequencies, thus providing the exquisite sensitivity and frequency-resolving capacity of the mammalian hearing organ. Prestin, a protein related to a sulfate/anion transport protein, recently has been identified and proposed as the OHC motor molecule. Homology searches of 1.5 kb of genomic DNA 5prime prime or minute of the coding region of the prestin gene allowed the identification of a thyroid hormone (TH) response element (TRE) in the first intron upstream of the prestin ATG codon. Prestin(TRE) bound TH receptors as a monomer or presumptive heterodimer and mediated a triiodothyronine-dependent transactivation of a heterologous promotor in response to triiodothyronine receptors alpha and beta. Retinoid X receptor-alpha had an additive effect. Expression of prestin mRNA and prestin protein was reduced strongly in the absence of TH. Although prestin protein typically was redistributed to the lateral membrane before the onset of hearing, an immature pattern of prestin protein distribution across the entire OHC membrane was noted in hypothyroid rats. The data suggest TH as a first transcriptional regulator of the motor protein prestin and as a direct or indirect modulator of subcellular prestin distribution.

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Biological Process

Cellular Component

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Slc26a5  (solute carrier family 26 member 5)


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