RGD Reference Report - Isolation and characterization of a cDNA for human mouse, and rat full-length stem cell growth factor, a new member of C-type lectin superfamily. - Rat Genome Database

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Isolation and characterization of a cDNA for human mouse, and rat full-length stem cell growth factor, a new member of C-type lectin superfamily.

Authors: Mio, H  Kagami, N  Yokokawa, S  Kawai, H  Nakagawa, S  Takeuchi, K  Sekine, S  Hiraoka, A 
Citation: Mio H, etal., Biochem Biophys Res Commun 1998 Aug 10;249(1):124-30.
RGD ID: 69976
Pubmed: PMID:9705843   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1998.9073   (Journal Full-text)

cDNA encoding stem cell growth factor (SCGF; 245 aa), a novel human growth factor for primitive hematopoietic progenitor cells, has been previously reported (Hiraoka, A., Sugimura, A., Seki, T., Nagasawa, T., Ohta, N., Shimonishi, M., Hagiya, M. and Shimizu, S. Proc. Natl. Acad. Sci. USA 94, 7577-7582, 1997). Here we report the cloning and characterization of a full-length SCGF cDNA. This protein consists of 323, 328 and 328 aa in the human, murine and rat forms, the latter two of which share 85.1% and 83.3% aa identity, and 90.4% and 90.4% aa similarity to the human protein, respectively. Because the newly identified human clone encodes the protein longer by 78 aa than that previously identified, we term the longer clone as hSCGF-alpha and the shorter one as hSCGF-beta. The computer-assisted homology search reveals that SCGF is a new member of the C-type lectin superfamily, and that SCGF shows the greatest homology to tetranectin among the members of the family (27.2-33.7% aa identity and 46.0-53.6% aa similarity). SCGF transcripts are detected in spleen, thymus, appendix, bone marrow and fetal liver. Fluorescent in situ hybridization mapping indicates that the SCGF gene is located on chromosome 19 at position q13.3 for human form and on chromosome 7 at position B3-B5 for murine form, which are close to flk-2/flt3 ligand and interleukin-11 genes of both human and murine species.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
carbohydrate binding enablesNAS 69976PMID:9705843UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Clec11a  (C-type lectin domain containing 11A)

Objects referenced in this article
Gene Clec11a C-type lectin domain family 11, member a Mus musculus

Additional Information