RGD Reference Report - SCAMP 37, a new marker within the general cell surface recycling system. - Rat Genome Database

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SCAMP 37, a new marker within the general cell surface recycling system.

Authors: Brand, SH  Castle, JD 
Citation: Brand SH and Castle JD, EMBO J 1993 Oct;12(10):3753-61.
RGD ID: 69975
Pubmed: PMID:8404846   (View Abstract at PubMed)
PMCID: PMC413657   (View Article at PubMed Central)

Secretory carrier membrane proteins (SCAMPs) are widely distributed as components of post-Golgi membranes that function as recycling carriers to the cell surface. In fibroblasts, SCAMPs are concentrated in compartments involved in the endocytosis and recycling of cell surface receptors while in neurons and other cell types having regulated transport pathways, SCAMPs are also components of regulated carriers (synaptic vesicles, secretion granules and transporter vesicles). Their presence in multiple pathways distinguishes them from proteins (e.g. recycling cell surface receptors and synaptic vesicle proteins) which are concentrated in selected pathways. The SCAMPs also do not appear to reside beyond the boundaries of these pathways. This distribution suggests that SCAMPs are general markers of membranes that function in cell surface recycling. The primary sequence of SCAMP 37 reveals a novel polypeptide containing a series of structural motifs, including a calcium binding domain, a leucine zipper and two zinc fingers. The very broad tissue distribution, subcellular localization and sequence analysis all predict that SCAMPs play a fundamental role in cell surface recycling.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
synaptic vesicle membrane is_active_inIDA 69975PMID:8404846SynGO 
synaptic vesicle membrane is_active_inIEP 69975PMID:8404846SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Scamp1  (secretory carrier membrane protein 1)


Additional Information