RGD Reference Report - A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons. - Rat Genome Database

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A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons.

Authors: Smidt, MP  Van Schaick, HS  Lanctot, C  Tremblay, JJ  Cox, JJ  Van der Kleij, AA  Wolterink, G  Drouin, J  Burbach, JP 
Citation: Smidt MP, etal., Proc Natl Acad Sci U S A 1997 Nov 25;94(24):13305-10.
RGD ID: 69932
Pubmed: PMID:9371841   (View Abstract at PubMed)
PMCID: PMC24304   (View Article at PubMed Central)

The mesencephalic dopaminergic (mesDA) system regulates behavior and movement control and has been implicated in psychiatric and affective disorders. We have identified a bicoid-related homeobox gene, Ptx3, a member of the Ptx-subfamily, that is uniquely expressed in these neurons. Its expression starting at E11.5 in the developing mouse midbrain correlates with the appearance of mesDA neurons. The number of Ptx3-expressing neurons is reduced in Parkinson patients, and these neurons are absent from 6-hydroxydopamine-lesioned rats, an animal model for this disease. Thus, Ptx3 is a unique transcription factor marking the mesDA neurons at the exclusion of other dopaminergic neurons, and it may be involved in developmental determination of this neuronal lineage.

Objects referenced in this article
Gene Pitx3 paired-like homeodomain transcription factor 3 Mus musculus
Gene Pitx3 paired-like homeodomain 3 Rattus norvegicus

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