RGD Reference Report - DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries. - Rat Genome Database

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DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries.

Authors: Nakamura, T  Ruiz-Lozano, P  Lindner, V  Yabe, D  Taniwaki, M  Furukawa, Y  Kobuke, K  Tashiro, K  Lu, Z  Andon, NL  Schaub, R  Matsumori, A  Sasayama, S  Chien, KR  Honjo, T 
Citation: Nakamura T, etal., J Biol Chem 1999 Aug 6;274(32):22476-83.
RGD ID: 69830
Pubmed: PMID:10428823   (View Abstract at PubMed)

We have identified and characterized mouse, rat, and human cDNAs that encode a novel secreted protein of 448 amino acids named DANCE (developmental arteries and neural crest epidermal growth factor (EGF)-like). DANCE contains six calcium-binding EGF-like domains, one of which includes an RGD motif. Overexpression studies of recombinant DANCE protein document that DANCE is a secreted 66-kDa protein. DANCE and recently described protein S1-5 comprise a new EGF-like protein family. The human DANCE gene was mapped at chromosome 14q32.1. DANCE mRNA is mainly expressed in heart, ovary, and colon in adult human tissues. Expression profile analysis by in situ hybridization revealed prominent DANCE expression in developing arteries. DANCE is also expressed in neural crest cell derivatives, endocardial cushion tissue, and several other mesenchymal tissues. In adult vessels, DANCE expression is largely diminished but is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells that lose their ability to proliferate in late stage of injury. DANCE protein was shown to promote adhesion of endothelial cells through interaction of integrins and the RGD motif of DANCE. DANCE is thus a novel vascular ligand for integrin receptors and may play a role in vascular development and remodeling.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
arteriosclerosis  ISOFbln5 (Mus musculus)69830; 69830 RGD 
arteriosclerosis  IEP 69830 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
extracellular space  IDA 69830 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fbln5  (fibulin 5)

Genes (Mus musculus)
Fbln5  (fibulin 5)

Genes (Homo sapiens)
FBLN5  (fibulin 5)


Additional Information