RGD Reference Report - Asialoglycoprotein receptor genes are linked on chromosome 11 in the mouse. - Rat Genome Database

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Asialoglycoprotein receptor genes are linked on chromosome 11 in the mouse.

Authors: Sanford, JP  Elliott, RW  Doyle, D 
Citation: Sanford JP, etal., DNA 1988 Dec;7(10):721-8.
RGD ID: 69759
Pubmed: PMID:3234178   (View Abstract at PubMed)
DOI: DOI:10.1089/dna.1988.7.721   (Journal Full-text)

The asialoglycoprotein receptor on the hepatocyte plasma membrane recognizes galactose-terminated glycoproteins and internalizes them for subsequent degradation in lysosomes. The rat receptor, also known as rat hepatic lectin (RHL), is comprised of three protein subunits called RHL-1, RHL-2, and RHL-3; two genes code for RHL-1 and RHL-2/3, respectively. We have cloned and sequenced the gene for RHL-2/3, and demonstrated that homologous asialoglycoprotein receptor genes exist in the mouse genome. Biochemical studies have demonstrated that receptor subunits exhibit the same temporal expression during development and function in a coordinate manner. This study asks if mouse receptor genes are linked and thus could possibly respond to shared cis-acting regulatory elements. Using restriction fragment length polymorphisms (RFLPs) and recombinant inbred lines, we mapped two closely linked mouse hepatic lectin (MHL) genes to chromosome 11. Asgr is designated to name asialoglycoprotein gene loci. Coordinate regulation of this linked gene family is discussed.

Objects referenced in this article
Gene Asgr1 asialoglycoprotein receptor 1 Mus musculus
Gene Asgr2 asialoglycoprotein receptor 2 Mus musculus
Gene Sparc secreted acidic cysteine rich glycoprotein Mus musculus
Gene Asgr2 asialoglycoprotein receptor 2 Rattus norvegicus

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