RGD Reference Report - High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains. - Rat Genome Database

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High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains.

Authors: Cicila, GT  Garrett, MR  Lee, SJ  Liu, J  Dene, H  Rapp, JP 
Citation: Cicila GT, etal., Genomics 2001 Feb 15;72(1):51-60.
RGD ID: 69711
Pubmed: PMID:11247666   (View Abstract at PubMed)
DOI: DOI:10.1006/geno.2000.6442   (Journal Full-text)

It was previously shown using Dahl salt-sensitive (S) and salt-resistant (R) rats that a blood pressure quantitative trait locus (QTL) was present on rat chromosome 7. In the present work, this QTL was localized to a region less than 0.54 cM in size on the linkage map using a series of congenic strains. This region was contained in a single yeast artificial chromosome that was 220 kb long. This small segment still contained the primary candidate locus Cyp11b1 (11beta-hydroxylase), but the adjacent candidate genes Cyp11b2 (aldosterone synthase) and Cyp11b3 were ruled out. It is concluded that 11beta-hydroxylase, through its known genetic variants altering the production of 18-hydroxy-11-deoxy corticosterone, is very likely to account for the blood pressure QTL on chromosome 7 in the Dahl rat model of hypertension. This QTL accounts for about 23 mm Hg under the condition of 2% NaCl diet for 24 days. Copyright 2001 Academic Press.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp61Rathypertension  IDA  RGD 
Bp169RatHypotension  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp169Ratdecreased systemic arterial systolic blood pressure  QTM  RGD 
SS.SR-(D7Mco7-D7Wox19)/JrRatdecreased systemic arterial systolic blood pressure  IMP as compared to SS/Jr on 2% Nacl dietRGD 
SS.SR-(D7Rat16-D7Mgh5)/JrRatdecreased systemic arterial systolic blood pressure  IMP as compared to SS/Jr on 2% Nacl dietRGD 
SS.SR-(D7Rat16-D7Rat189)/JrRatdecreased systemic arterial systolic blood pressure  IMP as compared to SS/Jr on 2% Nacl dietRGD 
SS.SR-(D7Uia1-D7Mco7)/JrRatdecreased systemic arterial systolic blood pressure  IMP as compared to SS/Jr on 2% Nacl dietRGD 
Bp61Ratincreased systemic arterial blood pressure  QTM  RGD 

Objects Annotated

QTLs
Bp169  (Blood pressure QTL 169)
Bp61  (Blood pressure QTL 61)

Objects referenced in this article
QTL Bpq6_m blood pressure QTL 6 (mouse) Mus musculus
Gene Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 Rattus norvegicus
Strain SS.SR-(Cyp11b1)/Jr null Rattus norvegicus
Strain SS.SR-(D7Mco7-D7Rat81)/Jr null Rattus norvegicus
Strain SS.SR-(D7Rat16-D7Rat176)/Jr null Rattus norvegicus

Additional Information