RGD Reference Report - Linkage mapping of the Fos cellular oncogene (Fos) to rat chromosome 6 and its possible role in the regulation of compensatory renal growth. - Rat Genome Database

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Linkage mapping of the Fos cellular oncogene (Fos) to rat chromosome 6 and its possible role in the regulation of compensatory renal growth.

Authors: Pravenec, M  Zidek, V  Simakova, M  Vorlicek, J  Kren, V 
Citation: Pravenec M, etal., Folia Biol (Praha) 1998;44(5):151-3.
RGD ID: 69708
Pubmed: PMID:10732705   (View Abstract at PubMed)

Using the analysis of HXB/BXH recombinant inbred (RI) strains, we have recently detected a suggestive association between the D6Mit9 marker and a compensatory growth of the remnant kidney after unilateral nephrectomy (P = 6 x 10(-)4). Based on conserved synteny between mice, rats, and humans, the putative quantitative trait locus (QTL) might map to a region with several positional candidate genes: for instance, the Fos oncogene was implicated as a possible candidate gene for compensatory renal growth (CRG). In the current study, we mapped the Fos gene in RI strains 27 cM apart from the position where the putative CRG regulatory QTL was detected. Despite relatively wide confidence intervals for mapping QTLs with modest effects in a small population of RI strains, this finding probably excludes the Fos as a positional candidate for CRG.

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
increased compensatory renal growth  QTM 69708 RGD 
Objects Annotated

QTLs
Coreg1  (Compensatory renal growth QTL 1)

Strains
BN-Lx/Cub  (Brown Norway with polydactyly-luxate)
SHR/Ola  (NA)

Objects referenced in this article
QTL Aia1 Adjuvant induced arthritis QTL 1 Rattus norvegicus
QTL Cia1 Collagen induced arthritis QTL 1 Rattus norvegicus
QTL Pia1 Pristane induced arthritis QTL 1 Rattus norvegicus

Additional Information