RGD Reference Report - Genetic mapping of blood pressure quantitative trait loci in Milan hypertensive rats. - Rat Genome Database

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Genetic mapping of blood pressure quantitative trait loci in Milan hypertensive rats.

Authors: Zagato, L  Modica, R  Florio, M  Torielli, L  Bihoreau, MT  Bianchi, G  Tripodi, G 
Citation: Zagato L, etal., Hypertension 2000 Nov;36(5):734-9.
RGD ID: 69692
Pubmed: PMID:11082136   (View Abstract at PubMed)

In a previous study, by using a candidate gene approach, we detected in both Milan hypertensive rats and humans a polymorphism in the alpha-adducin gene (ADD1) that was associated with blood pressure and renal sodium handling. In the present study, a genomewide search with 264 informative markers was undertaken in 251 (Milan hypertensive strain x Milan normotensive strain) F2 rats to further investigate the contribution of the adducin gene family (Add1, Add2, and Add3) and to identify novel quantitative trait loci (QTLs) that affect blood pressure. The influence of 2 different methods of blood pressure measurement, the intracarotid catheter and the tail-cuff method, was also evaluated. We found evidence that QTLs affected systolic blood pressure (SBP) measured at the carotid (direct SBP) on rat chromosome 1 with a logarithm of the odds (LOD) score peak of 3.3 on D1Rat121 and on rat chromosome 14 on Add1 locus (LOD=3.2). A QTL for SBP measured at the tail (indirect SBP) was found on rat chromosome 10 around D10Rat33 (LOD=5.0). All of these QTLs identified chromosomal regions not detected in other rat studies and harbor genes (Na(+)/H(+) exchanger A3; alpha-adducin; alpha(1B)-adrenergic receptor) that may be involved in blood pressure regulation. Therefore, these findings may be relevant to human hypertension, also in consideration of the biochemical and pathophysiological similarities between MHS and a subgroup of patients of primary hypertension, which led to the identification of alpha-adducin as a candidate gene in both species.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp57Rathypertension  IDA  RGD 
Bp58Rathypertension  IDA  RGD 
Bp59Rathypertension  IDA  RGD 
Bp60Rathypertension  IDA  RGD 
MHS/GibRathypertension  IAGP compared to MNS/GibRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype


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Objects Annotated

QTLs
Bp57  (Blood pressure QTL 57)
Bp58  (Blood pressure QTL 58)
Bp59  (Blood pressure QTL 59)
Bp60  (Blood pressure QTL 60)

Strains
MHS/Gib  (Milan Hypertensive Strain)
MNS/Gib  (Milan Normotensive Strain)

Objects referenced in this article
Strain MHS/N Milan Hypertensive Strain Rattus norvegicus

Additional Information