RGD Reference Report - Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1. - Rat Genome Database

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Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1.

Authors: Xia, J  Zhang, X  Staudinger, J  Huganir, RL 
Citation: Xia J, etal., Neuron 1999 Jan;22(1):179-87.
RGD ID: 69384
Pubmed: PMID:10027300   (View Abstract at PubMed)

Synaptic clustering of neurotransmitter receptors is crucial for efficient signal transduction and integration in neurons. PDZ domain-containing proteins such as PSD-95/SAP90 interact with the intracellular C termini of a variety of receptors and are thought to be important in the targeting and anchoring of receptors to specific synapses. Here, we show that PICK1 (protein interacting with C kinase), a PDZ domain-containing protein, interacts with the C termini of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptors in vitro and in vivo. In neurons, PICK1 specifically colocalizes with AMPA receptors at excitatory synapses. Furthermore, PICK1 induces clustering of AMPA receptors in heterologous expression systems. These results suggest that PICK1 may play an important role in the modulation of synaptic transmission by regulating the synaptic targeting of AMPA receptors.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
receptor clustering involved_inIMP 69384PMID:10027300UniProt 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
postsynaptic density located_inIDA 69384; 69384PMID:10027300UniProt 
protein-containing complex part_ofIPIUniProtKB:Q9EP8069384; 69384PMID:10027300UniProt 
protein-containing complex part_ofIDA 69384PMID:10027300UniProt 
synapse located_inIDA 69384; 69384PMID:10027300UniProt 

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Gria2  (glutamate ionotropic receptor AMPA type subunit 2)
Gria3  (glutamate ionotropic receptor AMPA type subunit 3)
Pick1  (protein interacting with PRKCA 1)


Additional Information