RGD Reference Report - Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein. - Rat Genome Database

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Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein.

Authors: Prior, P  Schmitt, B  Grenningloh, G  Pribilla, I  Multhaup, G  Beyreuther, K  Maulet, Y  Werner, P  Langosch, D  Kirsch, J 
Citation: Prior P, etal., Neuron 1992 Jun;8(6):1161-70.
RGD ID: 69377
Pubmed: PMID:1319186   (View Abstract at PubMed)

A 93 kd polypeptide associated with the mammalian inhibitory glycine receptor (GlyR) is localized at central synapses and binds with high affinity to polymerized tubulin. This protein, named gephyrin (from the Greek gamma epsilon phi upsilon rho alpha, bridge), is thought to anchor the GlyR to subsynaptic microtubules. Here we report its primary structure deduced from cDNA and show that corresponding transcripts are found in all rat tissues examined. In brain, at least five different gephyrin mRNAs are generated by alternative splicing. Expression of gephyrin cDNAs in 293 kidney cells yields polypeptides reactive with a gephyrin-specific antibody, which coprecipitate with polymerized tubulin. Thus, gephyrin may define a novel type of microtubule-associated protein involved in membrane protein-cytoskeleton interactions.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein-macromolecule adaptor activity  TAS 69377 RGD 
tubulin binding  TAS 69377 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gphn  (gephyrin)

Objects referenced in this article
Gene GPHN gephyrin Homo sapiens

Additional Information