RGD Reference Report - The renin-angiotensin system contributes to renal fibrosis through regulation of fibrocytes. - Rat Genome Database

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The renin-angiotensin system contributes to renal fibrosis through regulation of fibrocytes.

Authors: Sakai, N  Wada, T  Matsushima, K  Bucala, R  Iwai, M  Horiuchi, M  Kaneko, S 
Citation: Sakai N, etal., J Hypertens. 2008 Apr;26(4):780-90.
RGD ID: 6903848
Pubmed: PMID:18327089   (View Abstract at PubMed)
DOI: DOI:10.1097/HJH.0b013e3282f3e9e6   (Journal Full-text)

BACKGROUND: The renin-angiotensin system is a major pathway in the pathogenesis of cardiovascular and renal diseases. Bone marrow-derived fibrocytes, which are dual positive for CD45 and type I collagen, are now considered to contribute to the pathogenesis of various fibrotic diseases. We hypothesized that fibrocytes might contribute to renal fibrosis by an angiotensin II dependent pathway. RESULTS: In murine models of renal fibrosis, angiotensin II type 2 receptor (AT2R)-deficient mice, when compared with wild-type mice, showed increased renal fibrosis and fibrocyte infiltration with a concomitant upregulation of renal transcripts of procollagen type I (alpha) (COL1A1). Fibrocyte numbers in the bone marrow also were increased in AT2R-deficient mice. By contrast, pharmacological inhibition of angiotensin II type 1 receptor (AT1R) with valsartan reduced the degree of renal fibrosis and the number of fibrocytes in both the kidney and the bone marrow. In isolated human fibrocytes, inhibition of AT2R signaling increased the angiotensin II-stimulated expression of type I collagen, whereas inhibition of AT1R decreased collagen synthesis. These results suggest that AT1R/AT2R signaling may contribute to the pathogenesis of renal fibrosis by at least two mechanisms: by regulating the number of fibrocytes in the bone marrow, and by activation of fibrocytes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Fibrosis  ISOAgtr2 (Mus musculus)6903848; 6903848associated with Ureteral Obstruction RGD 
Fibrosis  IMP 6903848associated with Ureteral Obstruction RGD 

Objects Annotated

Genes (Rattus norvegicus)
Agtr2  (angiotensin II receptor, type 2)

Genes (Mus musculus)
Agtr2  (angiotensin II receptor, type 2)

Genes (Homo sapiens)
AGTR2  (angiotensin II receptor type 2)


Additional Information