RGD Reference Report - Glomerular MYH9 expression is reduced by HIV-1. - Rat Genome Database

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Glomerular MYH9 expression is reduced by HIV-1.

Authors: Hays, T  D'Agati, VD  Garellek, JA  Warren, T  Trubin, ME  Hyink, DP  He, JC  Klotman, PE 
Citation: Hays T, etal., AIDS. 2012 Apr 24;26(7):797-803.
RGD ID: 6903274
Pubmed: PMID:22313957   (View Abstract at PubMed)
PMCID: PMC3913730   (View Article at PubMed Central)
DOI: DOI:10.1097/QAD.0b013e328351f6cf   (Journal Full-text)

BACKGROUND: The continuing disease burden of HIV-associated nephropathy (HIVAN) warrants better elucidation of its pathogenic mechanisms. Given that loss of MYH9 function causes a Mendelian renal disease, we hypothesized that renal expression of MYH9 is down-regulated by HIV-1 in HIVAN pathogenesis. METHOD AND RESULTS: Using immunofluorescence, we determined that glomerular expression of MYH9 was reduced in the kidneys of HIV-1 transgenic mice. We further determined that Myh9 expression was reduced in HIV-1 transgenic podocytes, statistically significantly at the protein level, and that MYH9 expression was significantly reduced at protein and message level in human podocytes transduced with HIV-1. In analyzing expression in human tissue, we confirmed that MYH9 is abundantly expressed in glomeruli, and podocytes specifically. Finally, we found that MYH9 expression was significantly reduced in human glomeruli in the setting of HIVAN. CONCLUSION: We conclude that the podocyte host response to HIV-1 includes down-regulation of MYH9 expression, and hypothesize that this down-regulation might play a role in the pathogenesis of HIVAN.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
AIDS-Associated Nephropathy  IEP 6903274protein:decreased expression:glomerulusRGD 
AIDS-Associated Nephropathy  ISOMYH9 (Homo sapiens)6903274; 6903274protein:decreased expression:glomerulusRGD 
human immunodeficiency virus infectious disease  ISOMyh9 (Mus musculus)6903274; 6903274protein:decreased expression:glomerulusRGD 
human immunodeficiency virus infectious disease  IEP 6903274protein:decreased expression:glomerulusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Myh9  (myosin, heavy chain 9)

Genes (Mus musculus)
Myh9  (myosin, heavy polypeptide 9, non-muscle)

Genes (Homo sapiens)
MYH9  (myosin heavy chain 9)


Additional Information