RGD Reference Report - Characteristics of photoreceptor PDE (PDE6): similarities and differences to PDE5. - Rat Genome Database

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Characteristics of photoreceptor PDE (PDE6): similarities and differences to PDE5.

Authors: Cote, RH 
Citation: Cote RH Int J Impot Res. 2004 Jun;16 Suppl 1:S28-33.
RGD ID: 6893540
Pubmed: PMID:15224133   (View Abstract at PubMed)
DOI: DOI:10.1038/sj.ijir.3901212   (Journal Full-text)

Phosphodiesterase 6 (PDE6) is highly concentrated in the retina. It is most abundant in the internal membranes of retinal photoreceptors, where it reduces cytoplasmic levels of cyclic guanosine monophosphate (cGMP) in rod and cone outer segments in response to light. The rod PDE6 holoenzyme comprises alpha and beta catalytic subunits and two identical inhibitory gamma subunits. Each catalytic subunit contains three distinct globular domains corresponding to the catalytic domain and two GAF domains (responsible for allosteric cGMP binding). The PDE6 catalytic subunits resemble PDE5 in amino-acid sequence as well as in three-dimensional structure of the catalytic dimer; preference for cGMP over cyclic adenosine monophosphate (cAMP) as a substrate; and the ability to bind cGMP at the regulatory GAF domains. Most PDE5 inhibitors inhibit PDE6 with similar potency, and electroretinogram studies show modest effects of PDE5 inhibitors on visual function-an observation potentially important in designing PDE5-specific therapeutic agents.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Pde6a  (phosphodiesterase 6A)
Pde6b  (phosphodiesterase 6B)
Pde6c  (phosphodiesterase 6C)
Pde6g  (phosphodiesterase 6G)
Pde6h  (phosphodiesterase 6H)

Genes (Mus musculus)
Pde6a  (phosphodiesterase 6A, cGMP-specific, rod, alpha)
Pde6b  (phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide)
Pde6c  (phosphodiesterase 6C, cGMP specific, cone, alpha prime)
Pde6g  (phosphodiesterase 6G, cGMP-specific, rod, gamma)
Pde6h  (phosphodiesterase 6H, cGMP-specific, cone, gamma)

Genes (Homo sapiens)
PDE6A  (phosphodiesterase 6A)
PDE6B  (phosphodiesterase 6B)
PDE6C  (phosphodiesterase 6C)
PDE6G  (phosphodiesterase 6G)
PDE6H  (phosphodiesterase 6H)


Additional Information