RGD Reference Report - IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. - Rat Genome Database

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IL-21R on T cells is critical for sustained functionality and control of chronic viral infection.

Authors: Frohlich, A  Kisielow, J  Schmitz, I  Freigang, S  Shamshiev, AT  Weber, J  Marsland, BJ  Oxenius, A  Kopf, M 
Citation: Frohlich A, etal., Science. 2009 Jun 19;324(5934):1576-80. Epub 2009 May 28.
RGD ID: 6892934
Pubmed: (View Article at PubMed) PMID:19478140
DOI: Full-text: DOI:10.1126/science.1172815

Chronic viral infection is often associated with the dysfunction of virus-specific T cells. Our studies using Il21r-deficient (Il21r-/-) mice now suggest that interleukin-21 (IL-21) is critical for the long-term maintenance and functionality of CD8+ T cells and the control of chronic lymphocytic choriomeningitis virus infection in mice. Cell-autonomous IL-21 receptor (IL-21R)-dependent signaling by CD8+ T cells was required for sustained cell proliferation and cytokine production during chronic infection. Il21r-/- mice showed normal CD8+ T cell expansion, effector function, memory homeostasis, and recall responses during acute and after resolved infection with several other nonpersistent viruses. These data suggest that IL-21R signaling is required for the maintenance of polyfunctional T cells during chronic viral infections and have implications for understanding the immune response to other persisting antigens, such as tumors.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Il21r  (interleukin 21 receptor)

Genes (Mus musculus)
Il21r  (interleukin 21 receptor)

Genes (Homo sapiens)
IL21R  (interleukin 21 receptor)


Additional Information