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Airway angiogenesis in patients with rhinitis and controlled asthma.

Authors: Kristan, SS  Malovrh, MM  Silar, M  Kern, I  Flezar, M  Kosnik, M  Suskovic, S  Korosec, P 
Citation: Kristan SS, etal., Clin Exp Allergy. 2009 Mar;39(3):354-60. Epub 2009 Jan 22.
Pubmed: (View Article at PubMed) PMID:19178538
DOI: Full-text: DOI:10.1111/j.1365-2222.2008.03170.x

BACKGROUND: Airway angiogenesis may be an important part of structural remodelling in the pathogenesis of asthma. The development of asthma is frequently preceded by rhinitis. OBJECTIVE: We sought to determine whether the levels of angiogenesis-related factors are elevated in airways of patients with rhinitis or controlled asthma. METHODS: We analysed the induced sputum of 18 rhinitis patients, 16 asthmatic patients, and 15 healthy controls. The concentrations of angiogenin, vascular endothelial growth factor (VEGF), IL-8, fibroblast growth factor (bFGF), and TNF-alpha were measured by cytometric bead arrays. RESULTS: We found significantly increased angiogenin and VEGF concentrations in the induced sputum supernatant of both rhinitis and asthma patients compared with that of the healthy control group (P< or =0.0005). With the exception of TNF-alpha, there was no difference in the other angiogenic factors; TNF-alpha levels were higher in the rhinitis group than in the control group (P=0.02). CONCLUSION: These in vivo results suggest increased airway angiogenesis in patients with rhinitis without asthma as well as in corticosteroid-treated and well-controlled asthma patients.


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RGD Object Information
RGD ID: 6892723
Created: 2012-08-14
Species: All species
Last Modified: 2012-08-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.