RGD Reference Report - Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. - Rat Genome Database

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Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin.

Authors: Naisbitt, S  Kim, E  Tu, JC  Xiao, B  Sala, C  Valtschanoff, J  Weinberg, RJ  Worley, PF  Sheng, M 
Citation: Naisbitt S, etal., Neuron 1999 Jul;23(3):569-82.
RGD ID: 68848
Pubmed: PMID:10433268   (View Abstract at PubMed)

NMDA receptors are linked to intracellular cytoskeletal and signaling molecules via the PSD-95 protein complex. We report a novel family of postsynaptic density (PSD) proteins, termed Shank, that binds via its PDZ domain to the C terminus of PSD-95-associated protein GKAP. A ternary complex of Shank/GKAP/PSD-95 assembles in heterologous cells and can be coimmunoprecipitated from rat brain. Synaptic localization of Shank in neurons is inhibited by a GKAP splice variant that lacks the Shank-binding C terminus. In addition to its PDZ domain, Shank contains a proline-rich region that binds to cortactin and a SAM domain that mediates multimerization. Shank may function as a scaffold protein in the PSD, potentially cross-linking NMDA receptor/PSD-95 complexes and coupling them to regulators of the actin cytoskeleton.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  

Objects Annotated

Genes (Rattus norvegicus)
Dlg4  (discs large MAGUK scaffold protein 4)
Dlgap1  (DLG associated protein 1)
Kcna4  (potassium voltage-gated channel subfamily A member 4)
Shank1  (SH3 and multiple ankyrin repeat domains 1)
Shank3  (SH3 and multiple ankyrin repeat domains 3)


Additional Information