RGD Reference Report - Existence of distinct sodium channel messenger RNAs in rat brain. - Rat Genome Database

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Existence of distinct sodium channel messenger RNAs in rat brain.

Authors: Noda, M  Ikeda, T  Kayano, T  Suzuki, H  Takeshima, H  Kurasaki, M  Takahashi, H  Numa, S 
Citation: Noda M, etal., Nature 1986 Mar 13-19;320(6058):188-92.
RGD ID: 68844
Pubmed: PMID:3754035   (View Abstract at PubMed)
DOI: DOI:10.1038/320188a0   (Journal Full-text)

The sodium channel is a voltage-gated ionic channel essential for the generation of action potentials. It has been reported that the sodium channels purified from the electric organ of Electrophorus electricus (electric eel) and from chick cardiac muscle consist of a single polypeptide of relative molecular mass (Mr) approximately 260,000 (260K), whereas those purified from rat brain and skeletal muscle contain, in addition to the large polypeptide, two or three smaller polypeptides of Mr 37-45K. Recently, we have elucidated the primary structure of the Electrophorus sodium channel by cloning and sequencing the DNA complementary to its messenger RNA. Despite the apparent homogeneity of the purified sodium channel preparations, several types of tetrodotoxin (or saxitoxin) binding sites or sodium currents have been observed in many excitable membranes. The occurrence of distinguishable populations of sodium channels may be attributable to different states of the same channel protein or to distinct channel proteins. We have now isolated complementary DNA clones derived from two distinct rat brain mRNAs encoding sodium channel large polypeptides and present here the complete amino-acid sequences of the two polypeptides (designated sodium channels I and II), as deduced from the cDNA sequences. A partial DNA sequence complementary to a third homologous mRNA from rat brain has also been cloned.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
neuronal action potential  TAS 68844; 68844 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
voltage-gated sodium channel activity  TAS 68844 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Scn1a  (sodium voltage-gated channel alpha subunit 1)
Scn2a  (sodium voltage-gated channel alpha subunit 2)


Additional Information