RGD Reference Report - Arcadlin is a neural activity-regulated cadherin involved in long term potentiation. - Rat Genome Database

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Arcadlin is a neural activity-regulated cadherin involved in long term potentiation.

Authors: Yamagata, K  Andreasson, KI  Sugiura, H  Maru, E  Dominique, M  Irie, Y  Miki, N  Hayashi, Y  Yoshioka, M  Kaneko, K  Kato, H  Worley, PF 
Citation: Yamagata K, etal., J Biol Chem 1999 Jul 2;274(27):19473-1979.
RGD ID: 68758
Pubmed: PMID:10383464   (View Abstract at PubMed)

Neural activity results in long term changes that underlie synaptic plasticity. To examine the molecular basis of activity-dependent plasticity, we have used differential cloning techniques to identify genes that are rapidly induced in brain neurons by synaptic activity. Here, we identify a novel cadherin molecule Arcadlin (activity-regulated cadherin-like protein). arcadlin mRNA is rapidly and transiently induced in hippocampal granule cells by seizures and by N-methyl-D-aspartate-dependent synaptic activity in long term potentiation. The extracellular domain of Arcadlin is most homologous to protocadherin-8; however, the cytoplasmic region is distinct from that of any cadherin family member. Arcadlin protein is expressed at the synapses and shows a homophilic binding activity in a Ca2+-dependent manner. Furthermore, application of Arcadlin antibody reduces excitatory postsynaptic potential amplitude and blocks long term potentiation in hippocampal slices. Its close homology with cadherins, its rapid inducibility by neural activity, and its involvement in synaptic transmission suggest that Arcadlin may play an important role in activity-induced synaptic reorganization underlying long term memory.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Schaffer collateral - CA1 synapse is_active_inEXP 68758PMID:10383464SynGO 
Schaffer collateral - CA1 synapse is_active_inIDA 68758PMID:10383464SynGO 
synapse is_active_inIDA 68758PMID:10383464SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Pcdh8  (protocadherin 8)


Additional Information