RGD Reference Report - A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. - Rat Genome Database

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A novel multigene family may encode odorant receptors: a molecular basis for odor recognition.

Authors: Buck, L  Axel, R 
Citation: Buck L and Axel R, Cell 1991 Apr 5;65(1):175-87.
RGD ID: 68281
Pubmed: PMID:1840504   (View Abstract at PubMed)

The mammalian olfactory system can recognize and discriminate a large number of different odorant molecules. The detection of chemically distinct odorants presumably results from the association of odorous ligands with specific receptors on olfactory sensory neurons. To address the problem of olfactory perception at a molecular level, we have cloned and characterized 18 different members of an extremely large multigene family that encodes seven transmembrane domain proteins whose expression is restricted to the olfactory epithelium. The members of this novel gene family are likely to encode a diverse family of odorant receptors.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
odorant binding  ISS 68281; 68281 RGD 
olfactory receptor activity  ISS 68281 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Or1f45  (olfactory receptor family 1 subfamily F member 45)
Or6f2  (olfactory receptor family 6 subfamily F member 2)
Or7a38c  (olfactory receptor family 7 subfamily A member 38C)

Objects referenced in this article
Gene OR1D2 olfactory receptor family 1 subfamily D member 2 Homo sapiens
Gene Olr1469 olfactory receptor Olr1469 Rattus norvegicus
Gene Olr1481 olfactory receptor 1481 Rattus norvegicus
Gene Olr1493 olfactory receptor gene Olr1493 Rattus norvegicus
Gene Olr1500 olfactory receptor 1500 Rattus norvegicus
Gene Or1e16 olfactory receptor family 1 subfamily E member 16 Rattus norvegicus
Gene Or1e31 olfactory receptor family 1 subfamily E member 30 Rattus norvegicus
Gene Or6a2 olfactory receptor family 6 subfamily A member 2 Rattus norvegicus
Gene Or7a37 olfactory receptor family 7 subfamily A member 37 Rattus norvegicus
Gene Ube2v2 ubiquitin conjugating enzyme E2 V2 Rattus norvegicus

Additional Information