RGD Reference Report - Cloning and characterization of a putative G-protein coupled receptor potentially involved in development. - Rat Genome Database

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Cloning and characterization of a putative G-protein coupled receptor potentially involved in development.

Authors: MacLennan, AJ  Browe, CS  Gaskin, AA  Lado, DC  Shaw, G 
Citation: MacLennan AJ, etal., Mol Cell Neurosci 1994 Jun;5(3):201-9.
RGD ID: 68254
Pubmed: PMID:8087418   (View Abstract at PubMed)
DOI: DOI:10.1006/mcne.1994.1024   (Journal Full-text)

Polymerase chain reaction techniques and medium stringency library screening were used to isolate a rat cDNA ("H218") which encodes a novel guanine nucleotide-binding protein coupled receptor homolog ("pH218"). Northern analysis revealed that brain H218 mRNA is preferentially expressed during embryogenesis. In addition, H218 mRNA is expressed in all developing tissues and rodent cell lines examined with highest levels detected in primitive, transformed cells. H218 mRNA expression in cell lines is rapidly increased by a tumor promoter and rapidly decreased by a differentiation-inducing growth factor. Finally, all of the sequence motifs characteristic of Src homology 2 domains are present in pH218 but in a unique arrangement. We conclude that pH218 may function as a growth factor receptor.

Objects referenced in this article
Gene S1PR2 sphingosine-1-phosphate receptor 2 Homo sapiens
Gene S1pr2 sphingosine-1-phosphate receptor 2 Rattus norvegicus

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