RGD Reference Report - Specific alteration in the expression of glial fibrillary acidic protein, glutamate dehydrogenase, and glutamine synthetase in rats with genetic absence epilepsy. - Rat Genome Database

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Specific alteration in the expression of glial fibrillary acidic protein, glutamate dehydrogenase, and glutamine synthetase in rats with genetic absence epilepsy.

Authors: Dutuit, M  Didier-Bazes, M  Vergnes, M  Mutin, M  Conjard, A  Akaoka, H  Belin, MF  Touret, M 
Citation: Dutuit M, etal., Glia. 2000 Oct;32(1):15-24.
RGD ID: 6484590
Pubmed: PMID:10975907   (View Abstract at PubMed)

Astrocytes play a predominant role in energy metabolism and in the catabolism of gamma-aminobutyric acid (GABA) and glutamate, neurotransmitters critically involved in epileptic processes. We show specific astrocytic alterations in the genetic absence epilepsy rats from Strasbourg (GAERS). Spontaneous absence seizures appear in this strain in the cortex and thalamus after the age of 1 month. In these brain structures, we demonstrate increased GFAP expression in both adult and young GAERS, suggesting that reactive astrocytes are already present before the onset of seizures. Glutamate dehydrogenase (GDH) and glutamine synthetase (GS), which are localized mainly in astrocytes and involved in glutamate catabolism, are shown to be differentially altered. GDH expression was increased in the thalamus of both young and adult GAERS and in the cortex of young GAERS. GS expression was slightly decreased in the thalamus of young GAERS. These astrocytic modifications are not adaptive responses to seizures, as the modifications appear before the development of absence seizures. Thus, astrocytes might be involved in the neuronal processes giving rise to epileptic seizures in this strain.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
childhood absence epilepsy  ISOGlud1 (Rattus norvegicus)6484590; 6484590protein:increased expression:thalamusRGD 
childhood absence epilepsy  IEP 6484590protein:increased expression:thalamusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Glud1  (glutamate dehydrogenase 1)

Genes (Mus musculus)
Glud1  (glutamate dehydrogenase 1)

Genes (Homo sapiens)
GLUD1  (glutamate dehydrogenase 1)


Additional Information