RGD Reference Report - Increased levels of osteocalcin (serum bone Gla-protein) in rheumatoid arthritis. - Rat Genome Database

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Increased levels of osteocalcin (serum bone Gla-protein) in rheumatoid arthritis.

Authors: Gevers, G  Devos, P  De Roo, M  Dequeker, J 
Citation: Gevers G, etal., Br J Rheumatol. 1986 Aug;25(3):260-2.
RGD ID: 6483600
Pubmed: PMID:3488088   (View Abstract at PubMed)

Serum osteocalcin was measured by radio-immunoassay in 56 patients with rheumatoid arthritis (RA), and in 50 controls. Mean serum osteocalcin levels were significantly higher in patients with RA. There was a positive correlation between osteocalcin and fasting mucopolysaccharide/creatinine ratio in both sexes, and between osteocalcin and fasting hydroxyproline/creatinine ratio in women. Serum alkaline phosphatase activity, a less specific marker for bone formation, was also increased in RA, and there was a positive correlation with osteocalcin in both sexes. These data suggest that overall bone turnover is increased in RA and that serum osteocalcin may provide additional information for the evaluation of bone metabolism in this disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
rheumatoid arthritis  IEP 6483600protein:increased expression:serumRGD 
rheumatoid arthritis  ISOBGLAP (Homo sapiens)6483600; 6483600protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Bglap  (bone gamma-carboxyglutamate protein)

Genes (Mus musculus)
Bglap  (bone gamma carboxyglutamate protein)

Genes (Homo sapiens)
BGLAP  (bone gamma-carboxyglutamate protein)


Additional Information