RGD Reference Report - Radiographic hand osteoarthritis and serum levels of osteocalcin: cross-sectional study. - Rat Genome Database

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Radiographic hand osteoarthritis and serum levels of osteocalcin: cross-sectional study.

Authors: Kalichman, L  Kobyliansky, E 
Citation: Kalichman L and Kobyliansky E, Rheumatol Int. 2010 Jun;30(8):1131-5. Epub 2010 Feb 16.
RGD ID: 6483599
Pubmed: PMID:20157712   (View Abstract at PubMed)
DOI: DOI:10.1007/s00296-010-1372-y   (Journal Full-text)

The objective of this study is to evaluate the association between radiographic hand osteoarthritis and serum level of osteocalcin. The study population comprised Chuvashians (285 males, age 47.38 +/- 16.79; 265 females, age 48.55 +/- 15.94 years). OA was evaluated for 14 joints of each hand using Kellgren and Lawrence (K-L), joint space narrowing (JSN) and osteophytes (OS) scores. Plasma-intact osteocalcin was measured in 550 individuals by immunoradiometric assay using ELSA-OSTEO kit. Statistical analyses included multiple linear and logistic regressions. 51.64% of studied individuals had at least one finger joint affected at K-L > or = 2 level. JSN at the level > or = 2 was found in 9.82% and OS > or = 2 was found in 35.09% of the studied individuals. Osteocalcin showed a modest, but statistically significant, association with the number of affected joints according the K-L scale (beta = 0.082, p = 0.015), JSN scale (beta = 0.097, p = 0.025) and OS scale (beta = 0.078, p = 0.029). No significant association was found between the presence of at least one affected joint (K-L > or = 2 or OS > or = 2) and serum level of osteocalcin. Presence of at least one joint with space narrowing > or = 2 was significantly associated with serum level of osteocalcin (beta = 0.052, p = 0.023). In this cross-sectional population-based study, we found that serum level of osteocalcin is positively associated with severity of hand OA, measured by K-L, JSN and OS scales.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
osteoarthritis disease_progressionIDA 6483599 RGD 
osteoarthritis disease_progressionISOBGLAP (Homo sapiens)6483599; 6483599 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bglap  (bone gamma-carboxyglutamate protein)

Genes (Mus musculus)
Bglap  (bone gamma carboxyglutamate protein)

Genes (Homo sapiens)
BGLAP  (bone gamma-carboxyglutamate protein)


Additional Information