RGD Reference Report - The effect of vitamin K supplementation on biochemical markers of bone formation in children and adolescents with cystic fibrosis. - Rat Genome Database

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The effect of vitamin K supplementation on biochemical markers of bone formation in children and adolescents with cystic fibrosis.

Authors: Nicolaidou, P  Stavrinadis, I  Loukou, I  Papadopoulou, A  Georgouli, H  Douros, K  Priftis, KN  Gourgiotis, D  Matsinos, YG  Doudounakis, S 
Citation: Nicolaidou P, etal., Eur J Pediatr. 2006 Aug;165(8):540-5. Epub 2006 Apr 19.
RGD ID: 6483578
Pubmed: PMID:16622660   (View Abstract at PubMed)
DOI: DOI:10.1007/s00431-006-0132-1   (Journal Full-text)

INTRODUCTION: Impaired vitamin K status in cystic fibrosis (CF) has been considered as a newly emerged pathogenetic factor for reduced bone mineral density (BMD). OBJECTIVES: Our aim was to evaluate the effectiveness of vitamin K supplementation in managing bone formation abnormalities in children and adolescents with CF. MATERIALS AND METHODS: The statuses of vitamins K and D in relation to biochemical markers of bone metabolism and BMD were examined in 20 CF children receiving vitamin D supplements but not vitamin K supplements. Laboratory tests were carried out at the beginning of the study period and after 1 year of vitamin K supplementation (10 mg single oral dose/week) and the results were compared; the results were also compared with those of 25 healthy controls. RESULTS AND DISCUSSION: Ten of the CF patients had BMD z-score

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cystic fibrosis  IEP 6483578protein:decreased expression:serumRGD 
cystic fibrosis  ISOBGLAP (Homo sapiens)6483578; 6483578protein:decreased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Bglap  (bone gamma-carboxyglutamate protein)

Genes (Mus musculus)
Bglap  (bone gamma carboxyglutamate protein)

Genes (Homo sapiens)
BGLAP  (bone gamma-carboxyglutamate protein)


Additional Information