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Exploration of associations between phospholipase A2 gene family polymorphisms and AIDS progression using the SNPlex method.

Authors: Limou, S  Coulonges, C  Foglio, M  Heath, S  Diop, G  Leclerc, S  Hirtzig, T  Spadoni, JL  Therwath, A  Lambeau, G  Gut, I  Zagury, JF 
Citation: Limou S, etal., Biomed Pharmacother. 2008 Jan;62(1):31-40. Epub 2007 Dec 3.
Pubmed: (View Article at PubMed) PMID:18096355
DOI: Full-text: DOI:10.1016/j.biopha.2007.11.001

Members of the secreted phospholipase A2 (PLA2) protein family can inhibit HIV-1 virus replication in vitro. To evaluate the impact of PLA2 gene polymorphisms on AIDS disease development, we studied 12 family members using SNPlextrade mark technology that permitted simultaneous typing of 70 tagging Single Nucleotide Polymorphisms (tagSNPs). The study utilized HIV-1 seropositive donors with slow progressor (n=168) or rapid progressor (n=54) status, plus 355 control subjects. All donors were Caucasian (total 577 individuals). Genetic associations yielded mainly 0.01


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RGD Object Information
RGD ID: 6482728
Created: 2012-04-27
Species: All species
Last Modified: 2012-04-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.