RGD Reference Report - Changes of inflammation and apoptosis in adrenal gland after experimental injury in rats with acute necrotizing pancreatitis. - Rat Genome Database

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Changes of inflammation and apoptosis in adrenal gland after experimental injury in rats with acute necrotizing pancreatitis.

Authors: Yu, J  Xu, S  Wang, WX  Deng, WH  Jin, H  Chen, XY  Chen, C  Sun, HT 
Citation: Yu J, etal., Inflammation. 2012 Feb;35(1):11-22.
RGD ID: 6482719
Pubmed: PMID:21161352   (View Abstract at PubMed)
DOI: DOI:10.1007/s10753-010-9284-2   (Journal Full-text)

We hypothesize that adrenal insufficiency in acute necrotizing pancreatitis (ANP) is attributable to hemorrhagic inflammation, necrosis, and apoptosis of the adrenal cortex. Arguments to support this view are presented in the study that investigated morphological and functional changes of adrenal and the distinct roles of inflammatory mediator secretory phospholipase A(2) (sPLA(2)) and apoptosis-related genes Bax and Bcl-2 played in acute adrenal injury in ANP. After ANP model was induced, pancreatic histology, serum amylase, sPLA(2), and corticosterone were analyzed. The adrenal morphology, apoptotic cells by TUNEL assay, and ultrastructures were observed. sPLA(2)-IIA and Bcl-2 and Bax expressions were detected by immunohistochemistry. Histopathologic grading of adrenal was higher in ANP group than in controls. Serum corticosterone was stimulated to maximal level at 3 h, then dropped to the bottom at 24 h (P<0.05). Apoptotic index, sPLA2-IIA, and Bax expression were increased steeply after pancreatitis, and the Bax/Bcl-2 ratio was elevated gradually (P<0.05). Sustained decrease in serum corticosterone level following adrenal injury during ANP appears to be, in part, due to the crucial roles of inflammation and apoptosis in adrenal cortex. These findings could suggest that sPLA2, Bax, and Bcl-2 may be involved in the course of adrenal injury after ANP.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Adrenal Insufficiency  ISOBax (Rattus norvegicus)6482719; 6482719associated with Pancreatitis more ...RGD 
Adrenal Insufficiency  ISOBcl2 (Rattus norvegicus)6482719; 6482719associated with Pancreatitis more ...RGD 
Adrenal Insufficiency  IEP 6482719associated with Pancreatitis more ...RGD 
Adrenal Insufficiency  IEP 6482719associated with Pancreatitis more ...RGD 
Adrenal Insufficiency  ISOPla2g2a (Rattus norvegicus)6482719; 6482719associated with Pancreatitis more ...RGD 
Adrenal Insufficiency  IEP 6482719associated with Pancreatitis more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bax  (BCL2 associated X, apoptosis regulator)
Bcl2  (BCL2, apoptosis regulator)
Pla2g2a  (phospholipase A2 group IIA)

Genes (Mus musculus)
Bax  (BCL2-associated X protein)
Bcl2  (B cell leukemia/lymphoma 2)
Pla2g2a  (phospholipase A2, group IIA (platelets, synovial fluid))

Genes (Homo sapiens)
BAX  (BCL2 associated X, apoptosis regulator)
BCL2  (BCL2 apoptosis regulator)
PLA2G2A  (phospholipase A2 group IIA)


Additional Information