RGD Reference Report - Elucidating the role of 5-HT(1A) and 5-HT(7) receptors on 8-OH-DPAT-induced behavioral recovery after experimental traumatic brain injury. - Rat Genome Database

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Elucidating the role of 5-HT(1A) and 5-HT(7) receptors on 8-OH-DPAT-induced behavioral recovery after experimental traumatic brain injury.

Authors: Yelleswarapu, NK  Tay, JK  Fryer, WM  Shah, MA  Garcia, AN  Cheng, JP  Kline, AE 
Citation: Yelleswarapu NK, etal., Neurosci Lett. 2012 Mar 21.
RGD ID: 6482178
Pubmed: PMID:22465320   (View Abstract at PubMed)
PMCID: PMC3328631   (View Article at PubMed Central)
DOI: DOI:10.1016/j.neulet.2012.03.033   (Journal Full-text)

8-OH-DPAT is a 5-HT(1A/7) receptor agonist that enhances behavioral recovery after traumatic brain injury (TBI). This study is a first attempt to decipher whether the benefits induced by 8-OH-DPAT after TBI are mediated by 5-HT(1A) or 5-HT(7) receptors. A single i.p. injection of 8-OH-DPAT (0.5mg/kg) alone or co-administered with either the 5-HT(1A) or 5-HT(7) receptor antagonists WAY 100635 (0.5mg/kg) or SB 269970 HCl (2.0mg/kg), respectively, or vehicle control (1.0mL/kg) was given 15min after cortical impact or sham injury. Function was assessed by established motor and cognitive tests. No difference in motor performance was observed among the TBI groups. Spatial acquisition was enhanced, relative to vehicle controls, by 8-OH-DPAT alone and when co-administered with WAY 100635, but not when combined with SB 269970 HCl. These data imply that 5-HT(1A) receptor antagonism does not abate the 8-OH-DPAT-induced cognitive benefits, but 5-HT(7) receptor antagonism does, which suggests that the 8-OH-DPAT-induced benefits in this single administration paradigm may be mediated more by 5-HT(7) versus 5-HT(1A) receptors. Evaluation of a specific 5-HT(7) receptor agonist will further elucidate the contribution of 5-HT(1A) and 5-HT(7) receptors on behavioral recovery conferred by acute 8-OH-DPAT treatment after TBI.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Brain Injuries  ISOHtr7 (Rattus norvegicus)6482178; 6482178 RGD 
Brain Injuries  IMP 6482178 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Htr7  (5-hydroxytryptamine receptor 7)

Genes (Mus musculus)
Htr7  (5-hydroxytryptamine (serotonin) receptor 7)

Genes (Homo sapiens)
HTR7  (5-hydroxytryptamine receptor 7)


Additional Information