RGD Reference Report - P2Y12 receptors play a significant role in the development of platelet microaggregation in patients with diabetes. - Rat Genome Database

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P2Y12 receptors play a significant role in the development of platelet microaggregation in patients with diabetes.

Authors: Matsuno, H  Tokuda, H  Ishisaki, A  Zhou, Y  Kitajima, Y  Kozawa, O 
Citation: Matsuno H, etal., J Clin Endocrinol Metab. 2005 Feb;90(2):920-7. Epub 2004 Oct 13.
RGD ID: 6480536
Pubmed: PMID:15483100   (View Abstract at PubMed)
DOI: DOI:10.1210/jc.2004-0137   (Journal Full-text)

Ninety-eight diabetic patients (type 2) were studied together with 24 healthy normotensive controls. Microaggregates (particle scale, <25 microm) of platelets were detected by a laser scattering system. Microaggregates in the control group showed a time-dependent reversible change; however, they existed continuously in 82 of 98 diabetic patients. When platelets of diabetics were stimulated by a shear stress alone without ADP, 74 also showed spontaneous and irreversible microaggregates even though they were not observed in all control subjects. In control subjects, microaggregates were inhibited by MRS2279 (a P2Y1 antagonist), but not AR-C69931MX (a P2Y12 antagonist). However, AR-C69931MX prevented irreversible microaggregates in diabetic patients. When either aspirin or ticlopidine was administered to diabetic patients with irreversible microaggregates, both drugs significantly decreased microaggregates induced by a low dose of ADP. Ticlopidine additionally reduced the microaggregates induced by shear stress alone. In conclusion, microaggregates of platelets via P2Y12 receptors could play a key role in the hypersensitivity of platelets in diabetic patients, and the measurement of microaggregation could be a useful marker to estimate of thrombogenesis. These findings present a possible new means for patients with diabetes to prevent ischemic events.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 2 diabetes mellitus  IMP 6480536 RGD 
type 2 diabetes mellitus  ISOP2RY12 (Homo sapiens)6480536; 6480536 RGD 

Objects Annotated

Genes (Rattus norvegicus)
P2ry12  (purinergic receptor P2Y12)

Genes (Mus musculus)
P2ry12  (purinergic receptor P2Y, G-protein coupled 12)

Genes (Homo sapiens)
P2RY12  (purinergic receptor P2Y12)


Additional Information