RGD Reference Report - Adrenal alpha(2)-adrenergic receptors in the aging normotensive and spontaneously hypertensive rat. - Rat Genome Database

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Adrenal alpha(2)-adrenergic receptors in the aging normotensive and spontaneously hypertensive rat.

Authors: Moura, E  Pinto, CE  Serrao, MP  Afonso, J  Vieira-Coelho, MA 
Citation: Moura E, etal., Neurobiol Aging. 2012 May;33(5):969-78. Epub 2010 Aug 5.
RGD ID: 6480490
Pubmed: PMID:20691504   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neurobiolaging.2010.06.021   (Journal Full-text)

This study investigates alpha(2)-adrenergic receptor (alpha(2)AR) mediated feedback inhibition of catecholamine release from the adrenal medulla of adult (52 weeks) and old (98 weeks) spontaneously hypertensive rats (SHR) and normotensive controls Wistar Kyoto (WKY) rats. Adrenal epinephrine content as well as the spontaneous and the nicotinic-evoked release of epinephrine were similar between adult SHR and WKY rats. Aging produced a significant reduction in epinephrine synthesis in WKY rats. In contrast, in SHR aging produced a significant increase in epinephrine release without significant changes in epinephrine synthesis. The alpha(2)AR agonist medetomidine abolished (80-90% inhibition) the nicotinic-evoked release of epinephrine in adult SHR and WKY rats. With aging, this effect was unaltered in WKY rats but was significantly decreased in SHR (30% inhibition). Adrenal alpha(2A)AR mRNA levels were significantly reduced in old SHR compared with age matched WKY rats. In conclusion, in aging the alpha(2)AR mediated feedback inhibition of epinephrine release from the adrenal medulla is preserved in WKY rats but compromised in SHR, resulting in increased epinephrine release.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADRA2AHumanhypertension  ISOAdra2a (Rattus norvegicus)mRNA:decreased expression:adrenal gland medulla RGD 
Adra2aRathypertension  IEP mRNA:decreased expression:adrenal gland medulla RGD 
Adra2aMousehypertension  ISOAdra2a (Rattus norvegicus)mRNA:decreased expression:adrenal gland medulla RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adra2a  (adrenoceptor alpha 2A)

Genes (Mus musculus)
Adra2a  (adrenergic receptor, alpha 2a)

Genes (Homo sapiens)
ADRA2A  (adrenoceptor alpha 2A)


Additional Information