RGD Reference Report - Antibody to intermediate filaments of the cytoskeleton in patients with Behcet's disease. - Rat Genome Database

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Antibody to intermediate filaments of the cytoskeleton in patients with Behcet's disease.

Authors: Akoglu, T  Kozakoglu, H  Akoglu, E 
Citation: Akoglu T, etal., Clin Immunol Immunopathol. 1986 Dec;41(3):427-32.
RGD ID: 6480476
Pubmed: (View Article at PubMed) PMID:3780056

Antibodies to 10-nm intermediate filaments (anti-IF) were determined in the sera of 30 patients with Behcet's disease (BD), in addition to C-reactive protein and C9, and an attempt has been made to determine whether the presence of anti-IF indicate disease activity. The vimentin type of anti-IF was found to be positive in 14 out of 30 patients with BD (47%), whereas it was positive in 35% of the patients with rheumatoid arthritis (20 cases), 16% of the patients with systemic lupus erythematosus (19 cases) and in only 9% of the normal controls. The anti-IF were predominantly IgG class and the titers in BD were significantly higher than those in normal controls. Out of the 14 patients with anti-IF, 10 showed significantly increased levels of serum C9 and 8 showed increased levels of CRP activity. Only one patient showed increased C9, but was negative for anti-IF and CRP. The presence of anti-IF in the patients' sera was found to be a more sensitive indicator, though not specific, for the clinical assessment of disease activity.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Vim  (vimentin)

Genes (Mus musculus)
Vim  (vimentin)

Genes (Homo sapiens)
VIM  (vimentin)


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