RGD Reference Report - Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1. - Rat Genome Database

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Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1.

Authors: Leung, MK  Jones, T  Michels, CL  Livingston, DM  Bhattacharya, S 
Citation: Leung MK, etal., Genomics 1999 Nov 1;61(3):307-13.
RGD ID: 634741
Pubmed: PMID:10552932   (View Abstract at PubMed)
DOI: DOI:10.1006/geno.1999.5970   (Journal Full-text)

P35srj is a ubiquitously expressed nuclear protein that binds the transcriptional coactivators p300 and CREB-binding protein (CBP). It is an alternatively spliced isoform of Mrg1, a cytokine-inducible factor that has transformation activity. P35srj interferes with the recruitment of p300/CBP by the transcription factor HIF-1alpha, a process that is essential for the transcriptional response to hypoxia. Here we report the cloning of the human gene CITED2, which encodes p35srj and Mrg1. The CITED2 gene is composed of three exons and two introns. An unusually large (3 kb) CpG island covers both the promoter and the transcribed portions of the gene. The 5'-flanking region of the gene is active as a promoter in transient transfection assays and contains multiple STAT-binding sites, in keeping with its responsiveness to different cytokines. Fluorescence in situ hybridization, and identity to a known human sequence-tagged site (D6S2114), was used to map the CITED2 gene to chromosome 6q23.3.

Objects referenced in this article
Gene CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 Homo sapiens
Gene Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 Rattus norvegicus

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